Lebedev A A, Novikova R F
Farmakol Toksikol. 1989 Mar-Apr;52(2):43-6.
Experiments on rat tissues in vitro showed that the effect of furosemide on the activity of lactate dehydrogenase significantly changes against the background of the action of 2M urea. Furosemide decreases the activity of urea-stable fractions of lactate dehydrogenase in the kidney tissues at concentrations of 10(-6) and 10(-7) M, whereas in the liver and heart tissues this effect occurs at the concentration of 10(-3) M. However the introduction of furosemide in the incubation mixture before the addition of urea eliminates its inhibitory effect on lactate dehydrogenase activity in the kidney and its cortical layer at the concentration of 10(-6) M, in the medulla at 10(-5) M and in the liver and heart tissues only at 10(-3) M.
体外对大鼠组织进行的实验表明，在2M尿素作用的背景下，速尿对乳酸脱氢酶活性的影响会发生显著变化。速尿在浓度为10(-6)和10(-7) M时会降低肾组织中乳酸脱氢酶尿素稳定部分的活性，而在肝组织和心脏组织中，这种作用在浓度为10(-3) M时才会出现。然而，在添加尿素之前将速尿引入孵育混合物中，可消除其在浓度为10(-6) M时对肾及其皮质层中乳酸脱氢酶活性的抑制作用，在髓质中为10(-5) M，在肝组织和心脏组织中仅在10(-3) M时可消除。
