[肝脏中细胞色素P-450诱导过程中γ-氨基丁酸的免疫调节活性]
[The immunotropic activity of GABA during cytochrome P-450 induction in the liver].
作者信息
Kovalev I E, Riabinina N E
出版信息
Farmakol Toksikol. 1989 Mar-Apr;52(2):53-5.
PMID:2744145
Abstract
Gamma-aminobutyric acid (GABA) was shown to exert the immunodepressive effect. The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. The obtained data indicate the dependence of GABA pharmacological activity from the function of cytochrome P-450-dependent monooxygenase system of the liver.
摘要
γ-氨基丁酸（GABA）已被证明具有免疫抑制作用。在苯巴比妥或利福平诱导肝脏细胞色素P-450的情况下使用GABA，并未出现免疫抑制现象。所获得的数据表明，GABA的药理活性依赖于肝脏细胞色素P-450依赖性单加氧酶系统的功能。
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