Kuz'mitskiĭ B B, Dad'kov I G, Mashkovich A E, Stoma O V, Slepneva L M
Farmakol Toksikol. 1990 Mar-Apr;53(2):52-5.
Two structural analogues of D-homo-8-azasteroids, both an immunostimulant and an immunodepressant, are inductors of the liver cytochrome P-450 in animals. This capability was shown by means of both a decrease of the hexenal sleep duration in the pharmacological test and an increase of the quantity of cytochrome P-450 and the rate of N-demethylation of aminopyrine in the biochemical assays.
两种D-高-8-氮杂甾体结构类似物，兼具免疫刺激剂和免疫抑制剂的作用，是动物肝脏细胞色素P-450的诱导剂。通过药理学试验中己烯醛睡眠时间的缩短以及生化分析中细胞色素P-450数量的增加和氨基比林N-去甲基化速率的提高，证实了这种能力。
