Bates S, Sjödén P O, Fellenius J, Nyrén O
Department of Clinical Psychology, University Hospital, Uppsala University, Sweden.
Gastroenterology. 1989 Aug;97(2):376-83. doi: 10.1016/0016-5085(89)90073-5.
The etiology of gastric pain is an unsolved riddle, despite nearly a century of research. While much research and many pharmacologic treatment methods have been aimed at controlling acid secretion, the role of acid in reports of pain is unclear. In this study, 30 patients (10 with endoscopically verified duodenal ulcers, 10 with verified nonulcer dyspepsia, and 10 healthy volunteers) participated in a double-blind crossover study of the effects of ranitidine on pain reports after an injection of pentagastrin. The results showed that whereas pentagastrin caused a significant increase in gastric secretion, only the patients with nonulcer dyspepsia reported any appreciable pain before or after the injection. In addition, they chose more adjectives to describe their pain and reported more symptoms, especially directly after the injection. There were no significant differences between the drug and placebo conditions nor between the ulcer and healthy subjects. The role of acid in reported pain remains unclear.
尽管经过了近一个世纪的研究，但胃痛的病因仍是一个未解之谜。虽然许多研究和多种药物治疗方法都旨在控制胃酸分泌，但胃酸在疼痛报告中的作用尚不清楚。在本研究中，30名患者（10名经内镜证实患有十二指肠溃疡，10名经证实患有非溃疡性消化不良，10名健康志愿者）参与了一项关于雷尼替丁对注射五肽胃泌素后疼痛报告影响的双盲交叉研究。结果显示，虽然五肽胃泌素导致胃酸分泌显著增加，但只有非溃疡性消化不良患者在注射前后报告了任何明显的疼痛。此外，他们选择了更多形容词来描述疼痛，并报告了更多症状，尤其是在注射后不久。药物组与安慰剂组之间以及溃疡患者与健康受试者之间均无显著差异。胃酸在报告的疼痛中的作用仍不清楚。
