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本文引用的文献

1
Short course acid suppressive treatment for patients with functional dyspepsia: results depend on Helicobacter pylori status. The Frosch Study Group.功能性消化不良患者的短期抑酸治疗：结果取决于幽门螺杆菌状态。弗罗施研究小组
Gut. 2000 Oct;47(4):473-80. doi: 10.1136/gut.47.4.473.
2
How should Helicobacter pylori negative patients be managed?幽门螺杆菌阴性的患者应如何管理？
Gut. 1999 Jul;45 Suppl 1(Suppl 1):I32-5. doi: 10.1136/gut.45.2008.i32.
3
Impact of functional dyspepsia on quality of life and health care consumption after cessation of antisecretory treatment. A multicentre 3-month follow-up study.抗分泌治疗停止后功能性消化不良对生活质量和医疗保健消费的影响。一项多中心3个月随访研究。
Scand J Gastroenterol. 1999 Jun;34(6):566-74. doi: 10.1080/003655299750026010.
4
Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients.消化不良患者中外源性酸清除异常及十二指肠近端酸敏感性增加。
Gastroenterology. 1999 Mar;116(3):515-20. doi: 10.1016/s0016-5085(99)70171-x.
5
Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies).奥美拉唑治疗功能性消化不良的疗效：双盲、随机、安慰剂对照试验（邦德和歌剧研究）
Aliment Pharmacol Ther. 1998 Nov;12(11):1055-65. doi: 10.1046/j.1365-2036.1998.00410.x.
6
First line treatment with omeprazole provides an effective and superior alternative strategy in the management of dyspepsia compared to antacid/alginate liquid: a multicentre study in general practice.与抗酸剂/藻酸盐液体相比，奥美拉唑一线治疗在消化不良管理中提供了一种有效且更优的替代策略：一项全科医学多中心研究。
Aliment Pharmacol Ther. 1998 Feb;12(2):147-57. doi: 10.1046/j.1365-2036.1998.0284f.x.
7
The management of acid-related dyspepsia in general practice: a comparison of an omeprazole versus an antacid-alginate/ranitidine management strategy. Compete Research Group [corrected].全科医疗中酸相关性消化不良的管理：奥美拉唑与抗酸剂-藻酸盐/雷尼替丁管理策略的比较。竞争研究小组[已校正]
Aliment Pharmacol Ther. 1998 Mar;12(3):263-71. doi: 10.1046/j.1365-2036.1998.00282.x.
8
Lansoprazole 30 mg daily versus ranitidine 150 mg b.d. in the treatment of acid-related dyspepsia in general practice.在全科医疗中，兰索拉唑每日30毫克与雷尼替丁每日两次、每次150毫克治疗酸相关性消化不良的比较。
Aliment Pharmacol Ther. 1997 Jun;11(3):541-6. doi: 10.1046/j.1365-2036.1997.00179.x.
9
Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials.功能性消化不良的药物治疗：对试验方法的系统分析及对未来试验设计的建议
Am J Gastroenterol. 1996 Apr;91(4):660-73.
10
A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients.相当一部分非溃疡性消化不良患者的胃酸分泌异常情况与十二指肠溃疡患者相同。
Gut. 1995 Apr;36(4):534-8. doi: 10.1136/gut.36.4.534.

抑酸在功能性消化不良中的潜在作用：BOND、OPERA、PILOT和ENCORE研究

The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies.

作者信息

Talley N J, Lauritsen K

机构信息

Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, Australia.

出版信息

Gut. 2002 May;50 Suppl 4(Suppl 4):iv36-41. doi: 10.1136/gut.50.suppl_4.iv36.

DOI:10.1136/gut.50.suppl_4.iv36
PMID:11953346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1867693/
Abstract

Dyspepsia is a common condition in the general population but data are lacking on the benefits of effective acid inhibition with proton pump inhibitors in functional dyspepsia. The results of the large, randomised, double blind clinical trials, BOND and OPERA, the Scandinavian PILOT study, and a follow up study, ENCORE, are reviewed. BOND, OPERA, and PILOT aimed to address the question of whether effective acid inhibition with the proton pump inhibitor omeprazole relieves symptoms in patients with functional dyspepsia. ENCORE followed on from this, addressing the consequences of relieving symptoms in patients with functional dyspepsia once they are off therapy.

摘要

消化不良在普通人群中是一种常见病症，但关于质子泵抑制剂有效抑制胃酸对功能性消化不良的益处的数据尚缺。本文回顾了大型随机双盲临床试验BOND和OPERA、斯堪的纳维亚先导研究以及一项随访研究ENCORE的结果。BOND、OPERA和先导研究旨在解决质子泵抑制剂奥美拉唑有效抑制胃酸是否能缓解功能性消化不良患者症状这一问题。ENCORE在此基础上，探讨了功能性消化不良患者停止治疗后症状缓解的后果。