Elta G H, Behler E M, Colturi T J
Department of Internal Medicine, University of Michigan, Ann Arbor.
Am J Gastroenterol. 1990 Oct;85(10):1339-42.
Coffee and decaffeinated coffee stimulate acid secretion. In addition, many patients experience dyspepsia after coffee ingestion. Therefore, coffee is often prohibited by physicians in patients with peptic diseases. However, the association between peptic disease and symptoms remains unclear. This study compares coffee intake and the induction of symptoms by coffee in patients with duodenal ulcer disease, nonulcer dyspepsia, and normal controls. We have studied the coffee drinking habits of 58 duodenal ulcer patients, 55 nonulcer dyspepsia patients, and 55 normal controls. The use of coffee on a daily basis was not significantly different between duodenal ulcer patients (64%) and controls (56%), or between nonulcer dyspepsia patients (55%) and controls. There was also no difference between the three groups in the use of decaffeinated coffee, the number of cups per day, the method of preparation, the length of time of coffee use, or any change in coffee intake in the previous year. The intake of tea, caffeinated carbonated beverages, and aspirin or nonsteroidal anti-inflammatory drugs was also similar in the three groups. The duodenal ulcer patients were more likely to be cigarette smokers (45%) than either the controls (16%) or the nonulcer dyspepsia patients (24%). Daily alcohol intake was not significantly different in the three groups. The prevalence of coffee induction of dyspeptic symptoms was similar in duodenal ulcer patients (29%) and controls (22%), but was much more common in nonulcer dyspepsia patients (53%) than in controls (22%), p = 0.0036. In conclusion, there was no difference in coffee intake between patients with duodenal ulcer, nonulcer dyspepsia, or normal controls. However, patients with nonulcer dyspepsia, but not duodenal ulcer, were more likely to experience dyspeptic symptoms after coffee ingestion.
咖啡和脱咖啡因咖啡都会刺激胃酸分泌。此外，许多患者在摄入咖啡后会出现消化不良。因此，医生通常会禁止患有消化性疾病的患者喝咖啡。然而，消化性疾病与症状之间的关联仍不明确。本研究比较了十二指肠溃疡病患者、非溃疡性消化不良患者和正常对照组的咖啡摄入量以及咖啡诱发症状的情况。我们研究了58例十二指肠溃疡患者、55例非溃疡性消化不良患者和55例正常对照组的咖啡饮用习惯。十二指肠溃疡患者（64%）和对照组（56%）之间，以及非溃疡性消化不良患者（55%）和对照组之间，每日饮用咖啡的情况没有显著差异。在脱咖啡因咖啡的饮用、每日杯数、冲泡方法、饮用咖啡的时长或前一年咖啡摄入量的任何变化方面，三组之间也没有差异。三组中茶、含咖啡因碳酸饮料以及阿司匹林或非甾体抗炎药的摄入量也相似。十二指肠溃疡患者吸烟的可能性（45%）高于对照组（16%）或非溃疡性消化不良患者（24%）。三组的每日酒精摄入量没有显著差异。十二指肠溃疡患者（29%）和对照组（22%）中因咖啡诱发消化不良症状的发生率相似，但在非溃疡性消化不良患者（53%）中比对照组（22%）更为常见，p = 0.0036。总之，十二指肠溃疡患者、非溃疡性消化不良患者或正常对照组之间的咖啡摄入量没有差异。然而，非溃疡性消化不良患者而非十二指肠溃疡患者在摄入咖啡后更易出现消化不良症状。
