Olubuyide I O, Ayoola E A, Okubanjo A O, Atoba M A
Department of Medicine and Radiology, University College of Hospital, Ibadan, Nigeria.
Scand J Gastroenterol Suppl. 1986;124:83-7. doi: 10.3109/00365528609093787.
To determine the role of hyperacidity non-ulcer dyspepsia, forty-five Nigerians with this diagnosis were compared with twenty patients with proven duodenal ulcer with regard to their basal, maximal and peak acid outputs. The mean basal, maximal and peak acid outputs for the duodenal ulcer group were 6.72, 21.4 and 30.6 mol/h, respectively. In contrast, the corresponding values in non ulcer dyspepsia were 3.46, 13.03 and 17.83 mol/h respectively. This value in the two groups were significantly different. The efficacy of ranitidine at 300 mg daily for the control of the symptoms of non-ulcer dyspepsia was compared with placebo in a double-blind 4-weeks clinical trial. There was no significant difference in the response of the two groups comprising twenty-three and twenty-two patients, respectively. It is concluded that hyperacidity probably plays little role in non-ulcer dyspepsia and that the newer anti-ulcer drugs may be of little benefit under these circumstances.
为了确定胃酸过多在非溃疡性消化不良中的作用，将45名诊断为此病的尼日利亚人与20名确诊为十二指肠溃疡的患者进行了基础胃酸分泌量、最大胃酸分泌量和高峰胃酸分泌量的比较。十二指肠溃疡组的平均基础胃酸分泌量、最大胃酸分泌量和高峰胃酸分泌量分别为6.72、21.4和30.6毫摩尔/小时。相比之下，非溃疡性消化不良组的相应数值分别为3.46、13.03和17.83毫摩尔/小时。两组的这些数值有显著差异。在一项为期4周的双盲临床试验中，将雷尼替丁每日300毫克控制非溃疡性消化不良症状的疗效与安慰剂进行了比较。分别由23名和22名患者组成的两组的反应没有显著差异。得出的结论是，胃酸过多可能在非溃疡性消化不良中作用不大，在这种情况下，新型抗溃疡药物可能益处不大。
