[Siderophilic erythrokaryocytes of the bone marrow at various periods during the course of acute leukemia].

Investigation of the iron-containing granules in erythrokaryocytes of bone marrow from 89 patients with acute leukemias at different disease periods has demonstrated that siderophilia of the nuclear elements of red blood cells depends in many respects on the function of erythropoiesis which is materially influenced by various kinds of chemotherapy (induction, consolidation, maintenance and antirelapsing). Nevertheless, since the established correlation is marked to a moderate degree, the other factors may exist that influence granular siderophilia of medullary erythrokaryocytes, particularly the distribution of iron between the leukemic tissue and erythroid cells, manifesting dissimilarly in different patterns and variants of acute leukemias.