哪些人适合进行HIV暴露前预防？
To whom is HIV pre-exposure prophylaxis proposed?
作者信息
Ayerdi-Aguirrebengoa Oskar, Vera-García Mar, Puerta-López Teresa, Raposo-Utrilla Montserrat, Rodríguez-Martín Carmen, Del Romero-Guerrero Jorge
机构信息
Servicio de Urgencias, Hospital Fundación Jiménez Díaz, Madrid, España; Unidad de ITS/VIH, Centro Sanitario Sandoval IdISSC, Madrid, España.
Unidad de ITS/VIH, Centro Sanitario Sandoval IdISSC, Madrid, España.
出版信息
Enferm Infecc Microbiol Clin. 2017 May;35(5):299-302. doi: 10.1016/j.eimc.2016.06.006. Epub 2016 Jul 18.
INTRODUCTION
HIV Pre-Exposure Prophylaxis (PrEP) consists of administering antiretroviral drugs to seronegative individuals with high risk practices. The aim of the study was to describe the characteristics of recent seroconverted HIV patients in order to determine the profile of the appropriate candidates for PrEP.
METHODS
A descriptive study of all patients diagnosed with HIV infection in 2014, and who had achieved a documented negative serology over the previous 12 months. A specific form was completed to determine the sociodemographic, behavioural, and clinical features, with complementary tests being performed for other sexually transmitted infections.
RESULTS
Almost all (98.4%) of the 61 recent seroconverted were men who have sex with men, and aged between 20 to 39 years (88.5%). They also had a background of sexually transmitted infections (80.3%), performed multiple and unprotected sexual practices (82.7%), and under the effect of recreational drugs (87%).
CONCLUSIONS
The evaluation of the risk factors for HIV infection in seronegative patients should enable the appropriate candidates for PrEP to be identified.
引言
HIV暴露前预防（PrEP）包括向有高危行为的血清学阴性个体服用抗逆转录病毒药物。本研究的目的是描述近期血清学转换的HIV患者的特征，以便确定适合PrEP的候选人概况。
方法
对2014年诊断为HIV感染且在过去12个月血清学检测呈阴性记录的所有患者进行描述性研究。填写一份特定表格以确定社会人口统计学、行为学和临床特征，并对其他性传播感染进行补充检测。
结果
61例近期血清学转换患者中几乎所有（98.4%）为男男性行为者，年龄在20至39岁之间（88.5%）。他们也有性传播感染史（80.3%），有多次无保护性行为（82.7%），且受娱乐性药物影响（87%）。
结论
对血清学阴性患者的HIV感染危险因素进行评估应能识别出适合PrEP的候选人。
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