Department of Kinesiology, The University of Alabama, Tuscaloosa, Alabama, USA.
Department of Kinesiology, The University of Georgia, Athens, Georgia, USA.
Br J Sports Med. 2017 Apr;51(8):670-676. doi: 10.1136/bjsports-2016-095999. Epub 2016 Jul 21.
C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.
All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.
83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).
These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
C-反应蛋白（CRP）是一种常用于心血管疾病风险评估的慢性系统性炎症标志物。本荟萃分析的目的是提供一个定量估计，即在进行体育锻炼干预后 CRP 变化的幅度。
荟萃分析中包含的所有研究均经过同行评审，并以英文发表。将人类参与者分配到非运动对照组或运动训练组，干预持续时间≥2 周。在基线、运动训练计划期间和/或完成后测量 CRP 水平。使用随机效应模型汇总平均效应大小（ES）、95%置信区间和潜在的调节因素。
83 项随机和非随机对照试验符合纳入标准，共产生 143 项效应（n=3769）。0.26（95%CI 0.18 至 0.34，p<0.001）的平均 ES 表明 CRP 随运动训练而降低。体重指数（BMI；β=1.20，SE=0.25，p<0.0001）和%脂肪（β=0.76，SE=0.21，p=0.0002）的降低与 CRP 的降低有关，分别独立解释了 11.1%和 6.6%的反应变异。当 BMI 降低伴随着 CRP 的更大降低时（ES=0.38，95%CI 0.26 至 0.50），运动训练导致 CRP 更大程度的降低；然而，在没有体重减轻的情况下也会出现 CRP 的显著改善（ES=0.19，95%CI 0.10 至 0.28；两者均 p<0.001）。
这些结果表明，无论个体的年龄或性别如何，进行运动训练都与 CRP 水平的降低有关；然而，BMI 或%脂肪的降低会导致 CRP 水平的更大改善。
