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Korsakoff's syndrome on the MMPI-2.明尼苏达多相人格调查表第二版（MMPI-2）上的柯萨科夫综合征
Acta Neuropsychiatr. 2002 Oct;14(5):231-6. doi: 10.1034/j.1601-5215.2002.140506.x.
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Disease recognition is related to specific autobiographical memory deficits in alcohol-dependence.疾病识别与酒精依赖中的特定自传体记忆缺陷有关。
Psychiatry Res. 2015 Dec 15;230(2):157-64. doi: 10.1016/j.psychres.2015.08.031. Epub 2015 Aug 28.
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Denial in methamphetamine users: Associations with cognition and functional connectivity in brain.甲基苯丙胺使用者的否认现象：与大脑认知及功能连接的关联
Drug Alcohol Depend. 2015 Jun 1;151:84-91. doi: 10.1016/j.drugalcdep.2015.03.004. Epub 2015 Mar 18.
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Impaired self-awareness in human addiction: deficient attribution of personal relevance.人类成瘾中自我意识受损：个人相关性归因不足。
Trends Cogn Sci. 2014 Dec;18(12):635-41. doi: 10.1016/j.tics.2014.09.003. Epub 2014 Sep 30.
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INCOG recommendations for management of cognition following traumatic brain injury, part III: executive function and self-awareness.《脑外伤后认知管理的国际共识指南》第三部分：执行功能与自我意识
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Executive dysfunction in Korsakoff's syndrome: Time to revise the DSM criteria for alcohol-induced persisting amnestic disorder?科尔萨科夫综合征中的执行功能障碍：是时候修改 DSM 酒精所致持续性遗忘障碍的诊断标准了？
Int J Psychiatry Clin Pract. 2009;13(1):78-81. doi: 10.1080/13651500802308290.
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Functional, structural, and emotional correlates of impaired insight in cocaine addiction.可卡因成瘾患者洞察力受损的功能、结构和情感相关性。
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Executive functioning in chronic alcoholism and Korsakoff syndrome.慢性酒精中毒和柯萨科夫综合征患者的执行功能。
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使用Q8问卷评估酒精相关认知功能障碍患者的疾病洞察力：一项验证性研究。

Measuring illness insight in patients with alcohol-related cognitive dysfunction using the Q8 questionnaire: a validation study.

作者信息

Walvoort Serge Jw, van der Heijden Paul T, Kessels Roy Pc, Egger Jos Im

机构信息

Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray; Donders Institute for Brain, Cognition and Behaviour; Behavioural Science Institute, Radboud University, Nijmegen.

Behavioural Science Institute, Radboud University, Nijmegen; Reinier van Arkel Mental Health Institute, 's-Hertogenbosch.

出版信息

Neuropsychiatr Dis Treat. 2016 Jul 1;12:1609-15. doi: 10.2147/NDT.S104442. eCollection 2016.

DOI:10.2147/NDT.S104442
PMID:27445476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4936806/
Abstract

AIM

Impaired illness insight may hamper treatment outcome in patients with alcohol-related cognitive deficits. In this study, a short questionnaire for the assessment of illness insight (eg, the Q8) was investigated in patients with Korsakoff's syndrome (KS) and in alcohol use disorder (AUD) patients with mild neurocognitive deficits.

METHODS

First, reliability coefficients were computed and internal structure was investigated. Then, comparisons were made between patients with KS and patients with AUD. Furthermore, correlations with the Dysexecutive Questionnaire (DEX) were investigated. Finally, Q8 total scores were correlated with neuropsychological tests for processing speed, memory, and executive function.

RESULTS

Internal consistency of the Q8 was acceptable (ie, Cronbach's α =0.73). The Q8 items represent one factor, and scores differ significantly between AUD and KS patients. The Q8 total score, related to the DEX discrepancy score and scores on neuropsychological tests as was hypothesized, indicates that a higher degree of illness insight is associated with a higher level of cognitive functioning.

CONCLUSION

The Q8 is a short, valid, and easy-to-administer questionnaire to reliably assess illness insight in patients with moderate-to-severe alcohol-related cognitive dysfunction.

摘要

目的

疾病洞察力受损可能会妨碍酒精相关认知缺陷患者的治疗效果。在本研究中，对一种用于评估疾病洞察力的简短问卷（如Q8）在柯萨科夫综合征（KS）患者以及患有轻度神经认知缺陷的酒精使用障碍（AUD）患者中进行了调查。

方法

首先，计算信度系数并研究内部结构。然后，对KS患者和AUD患者进行比较。此外，研究了与执行功能障碍问卷（DEX）的相关性。最后，将Q8总分与处理速度、记忆和执行功能的神经心理学测试进行相关性分析。

结果

Q8的内部一致性是可接受的（即，克朗巴赫α系数=0.73）。Q8项目代表一个因素，AUD患者和KS患者的得分有显著差异。如假设的那样，与DEX差异得分和神经心理学测试得分相关的Q8总分表明，更高程度的疾病洞察力与更高水平的认知功能相关。

结论

Q8是一种简短、有效且易于实施的问卷，可用于可靠地评估中重度酒精相关认知功能障碍患者的疾病洞察力。