Tao Jie, Lan Zhen, Wang Yunman, Hei Hongya, Tian Lulu, Pan Wanma, Zhang Xuemei, Peng Wen
Department of Nephrology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, China.
Front Physiol. 2016 Jun 21;7:248. doi: 10.3389/fphys.2016.00248. eCollection 2016.
Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.
大电导钙激活钾（BK）通道目前被认为是多种肾脏生理过程中的关键参与者。在足细胞中，BK通道会对增加局部胞质Ca（2+）的刺激做出反应而激活，这可能继发于化学或机械刺激导致的裂孔隔膜TRPC6通道的激活。胰岛素通过调动BK通道增加滤过屏障的通透性。在系膜细胞中，与β1亚基共表达的BK通道是对收缩的反作用反应的主要组成部分，以调节肾小球滤过。这篇综述旨在突出关于BK通道在肾小球中的定位、生理和病理作用的最新发现。
