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宫颈癌组织学分级与正电子发射断层扫描参数之间的相关性

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma.

作者信息

Mocciaro Vanessa, Scollo Paolo, Stefano Alessandro, Gieri Stefania, Russo Giorgio, Scibilia Giuseppe, Cosentino Sebastiano, Murè Gabriella, Baldari Sara, Sabini Maria Gabriella, Fraggetta Filippo, Gilardi Maria Carla, Ippolito Massimo

机构信息

Institute of Molecular Bioimaging and Physiology, National Research Council, Cefalù, I-90015 Palermo, Italy.

Department of Gynecology, Cannizzaro Hospital, I-95126 Catania, Italy.

出版信息

Oncol Lett. 2016 Aug;12(2):1408-1414. doi: 10.3892/ol.2016.4771. Epub 2016 Jun 23.

DOI:10.3892/ol.2016.4771
PMID:27446445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4950245/
Abstract

The aim of the present study was to evaluate the changes in cervical cancer glucose metabolism for different levels of cellular differentiation. The metabolic activity was measured by standardized uptake value (SUV), SUV normalized to lean body mass, metabolic tumor volume and total lesion glycolysis using fluorine-18 fluorodeoxyglucose positron emission tomography (PET). A correlation study of these values could be used to facilitate therapeutic choice and to improve clinical practice and outcome. This study considered 32 patients with diagnosed cervical cancers, at different International Federation of Gynecology and Obstetrics stages. Glucose metabolism was assessed by PET examination, and histological specimens were examined to determine their initial grade of differentiation. A correlation study of these values was evaluated. Histological examination showed that all cases were of squamous cell carcinoma. Regarding the differentiation of the tumor, 19 well- to moderately-differentiated tumors and 13 poorly-differentiated tumors were determined. Negative findings for correlations between metabolic parameters and initial grade of histological differentiation were found, and considering that histological grade has been shown to have no consistent prognostic value in cervical cancer treatment, PET imaging could play a significant role in cervical cancer prognosis.

摘要

本研究的目的是评估不同细胞分化水平的宫颈癌葡萄糖代谢变化。使用氟-18氟脱氧葡萄糖正电子发射断层扫描（PET）通过标准化摄取值（SUV）、归一化去脂体重的SUV、代谢肿瘤体积和总病变糖酵解来测量代谢活性。对这些值进行相关性研究可有助于治疗选择并改善临床实践及治疗结果。本研究纳入了32例确诊为宫颈癌的患者，处于不同的国际妇产科联盟分期。通过PET检查评估葡萄糖代谢，并检查组织学标本以确定其初始分化程度。对这些值进行了相关性研究。组织学检查显示所有病例均为鳞状细胞癌。关于肿瘤的分化，确定了19例高分化至中分化肿瘤和13例低分化肿瘤。未发现代谢参数与组织学初始分化程度之间存在相关性，并且鉴于组织学分级在宫颈癌治疗中已被证明没有一致的预后价值，PET成像在宫颈癌预后中可能发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/c666b4b412c2/ol-12-02-1408-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/51be97bba5f2/ol-12-02-1408-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/349c71c104d2/ol-12-02-1408-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/cd08c52a68cb/ol-12-02-1408-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/d7ff540449d3/ol-12-02-1408-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/b9c78e199540/ol-12-02-1408-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/c666b4b412c2/ol-12-02-1408-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/51be97bba5f2/ol-12-02-1408-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/349c71c104d2/ol-12-02-1408-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/cd08c52a68cb/ol-12-02-1408-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/d7ff540449d3/ol-12-02-1408-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/b9c78e199540/ol-12-02-1408-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f68/4950245/c666b4b412c2/ol-12-02-1408-g05.jpg

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本文引用的文献

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Integrated PET/MRI for whole-body staging of patients with primary cervical cancer: preliminary results.集成正电子发射断层显像/磁共振成像用于原发性宫颈癌患者的全身分期：初步结果
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Outcome of international Federation of gynecology and obstetrics stage IIb cervical cancer from 2003 to 2012: an evaluation of treatments and prognosis: a retrospective study.
2003年至2012年国际妇产科联盟IIb期宫颈癌的治疗结果：治疗与预后评估：一项回顾性研究
Int J Gynecol Cancer. 2015 Jun;25(5):910-8. doi: 10.1097/IGC.0000000000000430.
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Maximum standardized uptake value of fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in ovarian clear cell adenocarcinoma.氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的最大标准化摄取值是卵巢透明细胞腺癌的一个预后因素。
Int J Gynecol Cancer. 2014 Sep;24(7):1190-4. doi: 10.1097/IGC.0000000000000180.
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Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology.核肿瘤学中使用基于体积和纹理的定量方法进行PET图像解读的最新趋势。
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