Stefano A, Gallivanone F, Messa C, Gilardi M C, Gastiglioni I
Q J Nucl Med Mol Imaging. 2014 Dec;58(4):413-23.
The aim of this work is to evaluate the metabolic impact of Partial Volume Correction (PVC) on the measurement of the Standard Uptake Value (SUV) from [18F]FDG PET-CT oncological studies for treatment monitoring purpose.
Twenty-nine breast cancer patients with bone lesions (42 lesions in total) underwent [18F]FDG PET-CT studies after surgical resection of breast cancer primitives, and before (PET-II) chemotherapy and hormone treatment. PVC of bone lesion uptake was performed on the two [18F]FDG PET-CT studies, using a method based on Recovery Coefficients (RC) and on an automatic measurement of lesion metabolic volume. Body-weight average SUV was calculated for each lesion, with and without PVC. The accuracy, reproducibility, clinical feasibility and the metabolic impact on treatment response of the considered PVC method was evaluated.
The PVC method was found clinically feasible in bone lesions, with an accuracy of 93% for lesion sphere-equivalent diameter >1 cm. Applying PVC, average SUV values increased, from 7% up to 154% considering both PET-I and PET-II studies, proving the need of the correction. As main finding, PVC modified the therapy response classification in 6 cases according to EORTC 1999 classification and in 5 cases according to PERCIST 1.0 classification.
PVC has an important metabolic impact on the assessment of tumor response to treatment by [18F]FDG PET-CT oncological studies.
本研究旨在评估部分容积校正（PVC）对[18F]FDG PET-CT肿瘤学研究中标准摄取值（SUV）测量的代谢影响，以用于治疗监测。
29例患有骨病变的乳腺癌患者（共42处病变）在乳腺癌原发灶手术切除后、化疗和激素治疗前（PET-II）接受了[18F]FDG PET-CT检查。在两项[18F]FDG PET-CT研究中，采用基于恢复系数（RC）和病变代谢体积自动测量的方法对骨病变摄取进行PVC。计算每个病变在有和无PVC情况下的体重平均SUV。评估了所考虑的PVC方法的准确性、可重复性、临床可行性以及对治疗反应的代谢影响。
发现PVC方法在骨病变中具有临床可行性，对于等效球直径>1 cm的病变，准确性为93%。应用PVC后，考虑PET-I和PET-II研究，平均SUV值增加了7%至154%，证明了校正的必要性。主要发现是，根据欧洲癌症研究与治疗组织（EORTC）1999年分类，PVC在6例中改变了治疗反应分类，根据实体瘤疗效评价标准（PERCIST）1.0分类，在5例中改变了治疗反应分类。
PVC对[18F]FDG PET-CT肿瘤学研究评估肿瘤治疗反应具有重要的代谢影响。
