Buskila D, Keystone E, Sukenik S
Harefuah. 1989 Apr 16;116(8):414-6.
Cases of polymyositis or dermatomyositis in which levels of all the serum muscle enzymes are within the normal range throughout the entire clinical course are very rare. It has recently been suggested that when there is no increase in creatine kinase the prognosis in dermatomyositis is poor and there is a higher incidence of malignancy and interstitial lung disease associated with the condition. We describe a rare case of dermatomyositis without increase in serum muscle enzymes, including creatine kinase. No evidence of malignancy or interstitial lung disease was found after a followup of 18 months. In accordance with the report of a similar case, we suggest that the absence of an increase in creatine kinase in dermatomyositis is not necessarily a poor prognostic sign.
在整个临床病程中血清肌酶水平均在正常范围内的多发性肌炎或皮肌炎病例非常罕见。最近有人提出,当肌酸激酶没有升高时,皮肌炎的预后较差,且与该疾病相关的恶性肿瘤和间质性肺病的发生率较高。我们描述了一例罕见的皮肌炎病例,其血清肌酶包括肌酸激酶没有升高。经过18个月的随访,未发现恶性肿瘤或间质性肺病的证据。根据类似病例的报告,我们认为皮肌炎中肌酸激酶不升高不一定是预后不良的迹象。