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本文引用的文献

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Wavelength-Modulated Differential Photoacoustic Spectroscopy (WM-DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring.波长调制差分光声光谱法（WM-DPAS）用于非侵入性早期癌症检测和组织缺氧监测。
J Biophotonics. 2016 Apr;9(4):388-95. doi: 10.1002/jbio.201500131. Epub 2015 May 21.
2
Broadband optical mammography: chromophore concentration and hemoglobin saturation contrast in breast cancer.宽带光学乳腺成像：乳腺癌中的发色团浓度和血红蛋白饱和度对比
PLoS One. 2015 Mar 17;10(3):e0117322. doi: 10.1371/journal.pone.0117322. eCollection 2015.
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Biomedical photoacoustic imaging.生物医学光声成像。
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Comparison between pulsed laser and frequency-domain photoacoustic modalities: signal-to-noise ratio, contrast, resolution, and maximum depth detectivity.脉冲激光与频域光声模态的比较：信噪比、对比度、分辨率和最大深度探测率。
Rev Sci Instrum. 2011 Sep;82(9):094903. doi: 10.1063/1.3632117.
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Heterogeneity in breast cancer.乳腺癌的异质性。
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Recent applications of near-infrared spectroscopy in cancer diagnosis and therapy.近红外光谱在癌症诊断与治疗中的最新应用。
Anal Bioanal Chem. 2008 Jan;390(1):125-39. doi: 10.1007/s00216-007-1651-y. Epub 2007 Oct 23.
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Breast tumor heterogeneity: cancer stem cells or clonal evolution?乳腺肿瘤异质性：癌症干细胞还是克隆进化？
Cell Cycle. 2007 Oct 1;6(19):2332-8. doi: 10.4161/cc.6.19.4914. Epub 2007 Aug 17.
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Intraoperatively assessed optical properties of malignant and healthy breast tissue used to determine the optimum wavelength of contrast for optical mammography.术中评估恶性和健康乳腺组织的光学特性，以确定光学乳腺造影的最佳对比波长。
J Biomed Opt. 2004 Nov-Dec;9(6):1129-36. doi: 10.1117/1.1803547.
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Spatial variations in optical and physiological properties of healthy breast tissue.健康乳腺组织光学和生理特性的空间变化。
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10
Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study.使用定量漫射光学光谱监测乳腺癌新辅助化疗：一项病例研究。
J Biomed Opt. 2004 Jan-Feb;9(1):230-8. doi: 10.1117/1.1629681.

波长调制差分光声雷达成像仪（WM-DPARI）：绝对血红蛋白氧饱和度的精确监测。

Wavelength-modulated differential photoacoustic radar imager (WM-DPARI): accurate monitoring of absolute hemoglobin oxygen saturation.

作者信息

Choi Sung Soo Sean, Lashkari Bahman, Dovlo Edem, Mandelis Andreas

机构信息

Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT), Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada.

出版信息

Biomed Opt Express. 2016 Jun 13;7(7):2586-96. doi: 10.1364/BOE.7.002586. eCollection 2016 Jul 1.

DOI:10.1364/BOE.7.002586
PMID:27446691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4948615/
Abstract

Accurate monitoring of blood oxy-saturation level (SO2 ) in human breast tissues is clinically important for predicting and evaluating possible tumor growth at the site. In this work, four different non-invasive frequency-domain photoacoustic (PA) imaging modalities were compared for their absolute SO2 characterization capability using an in-vitro sheep blood circulation system. Among different PA modes, a new WM-DPAR imaging modality could estimate the SO2 with great accuracy when compared to a commercial blood gas analyzer. The developed WM-DPARI theory was further validated by constructing SO2 tomographic images of a blood-containing plastisol phantom.

摘要

准确监测人体乳腺组织中的血氧饱和度水平（SO2）对于预测和评估该部位可能的肿瘤生长具有重要的临床意义。在这项工作中，使用体外羊血液循环系统比较了四种不同的非侵入性频域光声（PA）成像模式对SO2的绝对表征能力。在不同的PA模式中，一种新的WM-DPAR成像模式与商用血气分析仪相比，能够非常准确地估计SO2。通过构建含血增塑溶胶体模的SO2断层图像，进一步验证了所提出的WM-DPARI理论。