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居住在靠近石油终端且环境暴露于挥发性有机化合物地区的小学生的健康问题

Health Issues of Primary School Students Residing in Proximity of an Oil Terminal with Environmental Exposure to Volatile Organic Compounds.

作者信息

Cipolla Massimo, Bruzzone Marco, Stagnaro Emanuele, Ceppi Marcello, Izzotti Alberto, Culotta Claudio, Piccardo Maria Teresa

机构信息

Mutagenesis Unit, IRCCS AOU San Martino-IST, Istituto Nazionale Ricerca sul Cancro, 16132 Genoa, Italy.

Clinical Epidemiology Unit, IRCCS AOU San Martino-IST, Istituto Nazionale Ricerca sul Cancro, 16132 Genoa, Italy.

出版信息

Biomed Res Int. 2016;2016:4574138. doi: 10.1155/2016/4574138. Epub 2016 Jul 3.

Abstract

Residential proximity to industrial sites has been associated with adverse effects on human health. Children are more susceptible to airborne environmental exposure because their immune and respiratory systems are still developing. This study aimed to investigate whether living close to an oil terminal in Genoa where there is higher VOCs exposure is associated with an increased rate of school absenteeism because of disease in primary school children. Five schools were chosen for the recruitment of children and students residing in the industrial site (A) were compared to those living in residential sites (B). Sixty-six of the 407 students involved in the project were also selected for VOC monitoring. Source apportionment was carried out by comparing profiles of VOCs; principal component analysis was performed to study the correlation between profiles, and Kriging interpolation model was used to extend profiles to all participants. The concentration means of total VOCs were significantly higher in the industrial areas compared to controls. Adjusting for potential confounders, children who lived in area A had a significantly higher risk of being absent from school due to sore throat, cough, and cold compared to controls. o-Xylene, which is dispersed during the industrial activity, showed clear evidence of a significant association with respiratory symptoms.

摘要

居住在工业场所附近与对人类健康的不利影响有关。儿童更容易受到空气传播的环境暴露影响,因为他们的免疫系统和呼吸系统仍在发育。本研究旨在调查居住在热那亚一个石油码头附近(那里有更高的挥发性有机化合物暴露)是否与小学儿童因疾病导致的旷课率增加有关。选择了五所学校招募儿童,并将居住在工业场所(A)的学生与居住在居民区(B)的学生进行比较。参与该项目的407名学生中有66名也被选来进行挥发性有机化合物监测。通过比较挥发性有机化合物的特征进行源解析;进行主成分分析以研究特征之间的相关性,并使用克里金插值模型将特征扩展到所有参与者。与对照组相比,工业区总挥发性有机化合物的浓度均值显著更高。在对潜在混杂因素进行调整后,与对照组相比,居住在A区的儿童因喉咙痛、咳嗽和感冒而缺课的风险显著更高。在工业活动中扩散的邻二甲苯显示出与呼吸道症状有显著关联的明确证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bf9/4947509/a4eb7567084d/BMRI2016-4574138.001.jpg

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