Burmer G C, Rabinovitch P S, Kulander B G, Rusch V, McNutt M A
Department of Pathology, University of Washington School of Medicine, Seattle 98195.
Hum Pathol. 1989 Aug;20(8):777-83. doi: 10.1016/0046-8177(89)90072-5.
Forty-six cases of malignant pleural mesothelioma were analyzed for histologic subtype, DNA content, and cell cycle characteristics. Sixty-five percent of cases were diploid in DNA content, with intermediate to low proliferative rates. Thirty-one nonmesothelial malignant neoplasms of the lung, of histologic types most easily confused with malignant mesothelioma, were also examined. In contrast to the mesotheliomas, 85% of these nonmesothelial malignant neoplasms of the lung were aneuploid; the aneuploid neoplasms exhibited higher mean proliferative rates (S = 10.6%) than diploid nonmesothelial neoplasms of the lung (S less than 6%). Unlike most malignant neoplasms, mesotheliomas most often display diploid DNA contents and low proliferative rates despite their clinically aggressive behavior.
对46例恶性胸膜间皮瘤进行了组织学亚型、DNA含量及细胞周期特征分析。65%的病例DNA含量为二倍体，增殖率中等至较低。还检查了31例肺非间皮恶性肿瘤，其组织学类型最易与恶性间皮瘤混淆。与间皮瘤相反，这些肺非间皮恶性肿瘤中85%为非整倍体；非整倍体肿瘤的平均增殖率（S=10.6%）高于肺二倍体非间皮肿瘤（S<6%）。与大多数恶性肿瘤不同，间皮瘤尽管临床行为具有侵袭性，但最常表现为二倍体DNA含量和低增殖率。
