Lan N C, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes R S, Mohandas T, Shih J C
Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
Genomics. 1989 May;4(4):552-9. doi: 10.1016/0888-7543(89)90279-6.
Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
单胺氧化酶A和B（MAO A和B）是催化全身生物胺氧化脱氨的关键酶。分别使用人MAO A和B的全长cDNA克隆确定了X染色体上编码MAO A和B的基因的区域位置。通过体细胞杂种、原位杂交、脉冲场凝胶电泳以及对一名诺里病患者进行缺失定位分析，我们得出结论，这两个基因彼此相邻，且与DXS7基因座（Xp 11.3）相邻。
