吸烟对缺铁的吸烟和不吸烟孕妇转铁蛋白唾液酸化的影响。
Influence of tobacco smoking on transferrin sialylation during pregnancy in smoking and non-smoking women with iron deficiency.
机构信息
Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
出版信息
Environ Toxicol Pharmacol. 2016 Sep;46:95-102. doi: 10.1016/j.etap.2016.07.001. Epub 2016 Jul 6.
OBJECTIVES
Tobacco smoking influence on proteins is leading to despaired foetal nourishment. Transferrin, is an essential metal-binding protein responsible for iron transport and proper foetal development. This study examines influence of tobacco smoking on transferrin sialic acid residues and its connection to foetal nourishment at women with iron deficiency.
METHODS
The study involved 190 samples from pregnant women in 1st, 2nd and 3rd trimester. Women were divided in terms of tobacco smoking and iron deficiency.
RESULTS
During pregnancy, the levels of 2-, 5- and 6-sialo transferrin were increasing while 3- and 4-sialo transferrin were decreasing in all groups. Transferrin isoforms showed positive correlation with lowered iron stores in the blood of non-smoking women.
CONCLUSION
Tobacco smoking has an influence on number of sialic acids residues in the transferrin and seems to change conversion of Tf isoforms, and this may disturb iron transport and in consequence influence on foetal development and nourishment.
目的
吸烟对蛋白质的影响导致胎儿营养供应不足。转铁蛋白是一种重要的金属结合蛋白，负责铁的运输和胎儿的正常发育。本研究探讨了吸烟对缺铁孕妇转铁蛋白唾液酸残基的影响及其与胎儿营养的关系。
方法
该研究纳入了 190 名处于孕 1 、 2 、 3 期的孕妇样本。根据吸烟和缺铁情况对孕妇进行分组。
结果
在整个孕期， 2- 、 5- 、 6-唾液酸转铁蛋白的水平逐渐增加，而 3- 、 4-唾液酸转铁蛋白的水平逐渐减少。在不吸烟的女性中，转铁蛋白同工型与血液中铁储量的降低呈正相关。
结论
吸烟会影响转铁蛋白中唾液酸残基的数量，并可能改变 Tf 同工型的转化，从而干扰铁的运输，进而影响胎儿的发育和营养。
Zotero 插件