[意外再激发：两名老年女性发生的全身性大疱性固定性药疹]

[Unintended rechallenge : Generalized bullous fixed drug eruption in two elderly women].

作者信息

Paulmann M, Mockenhaupt M

机构信息

Dokumentationszentrum schwerer Hautreaktionen, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

出版信息

Hautarzt. 2017 Jan;68(1):59-63. doi: 10.1007/s00105-016-3850-y.

DOI:10.1007/s00105-016-3850-y

PMID:27448063

Abstract

Severe bullous skin reactions like Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and generalized bullous fixed drug eruption (GBFDE) are rare, but occasionally fatal diseases which are mainly induced by drugs. We report about 2 women who both developed severe bullous skin reactions after domestic falls. Despite knowing the causative drug and having an allergy identification, both patients suffered from a secondary event after unintentional re-exposure.

摘要

严重的大疱性皮肤反应，如史蒂文斯-约翰逊综合征（SJS）、中毒性表皮坏死松解症（TEN）和全身性大疱性固定性药疹（GBFDE）虽罕见，但偶尔会致命，且主要由药物诱发。我们报告了2名女性，她们均在家庭跌倒后出现严重的大疱性皮肤反应。尽管知道致病药物并进行了过敏鉴定，但两名患者在无意中再次接触后均发生了二次事件。