Baird B J, De Villez R L
Division of Dermatology, University of Texas Health Science Center, San Antonio 78284.
Int J Dermatol. 1988 Apr;27(3):170-4. doi: 10.1111/j.1365-4362.1988.tb04923.x.
This paper is written to heighten awareness of the presence of the most severe form of fixed drug eruption. Two patients with a widespread bullous form of fixed drug eruption (FDE) were initially given the diagnosis of toxic epidermal necrolysis (TEN). Both gave a history of a previous widespread eruption from the responsible drug, each had biopsies consistent with fixed drug eruption, and most importantly, both had an uncomplicated course, with complete cutaneous reepithelialization within 10 days. These observations suggest that widespread bullous fixed drug eruption may portend a more favorable prognosis than TEN, thus stressing the potential importance of distinguishing the two diseases. A review of fixed drug eruption and possible means of differentiating the widespread bullous form from TEN are discussed.
撰写本文旨在提高对最严重形式的固定性药疹的认识。两名患有广泛大疱型固定性药疹（FDE）的患者最初被诊断为中毒性表皮坏死松解症（TEN）。两人均有既往因致病药物引发广泛皮疹的病史，各自的活检结果均符合固定性药疹，且最重要的是，两人病程均无并发症，在10天内皮肤完全重新上皮化。这些观察结果表明，广泛大疱型固定性药疹可能比TEN预后更良好，从而强调了区分这两种疾病的潜在重要性。本文讨论了固定性药疹以及将广泛大疱型与TEN进行鉴别的可能方法。
