闽南汉族23个Y染色体标记的单倍型数据及其与12个Y染色体标记单倍型数据的比较。
Haplotype data of 23 Y-chromosome markers in Minnan Han Chinese and comparison with those of 12 Y-chromosome markers.
作者信息
Shang Jie, Hu Sheng-Ping
机构信息
Molecular Biology and Forensic Genetics Laboratory, Shantou University Medical College, Shantou, 515031, China.
出版信息
J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):456-463. doi: 10.1007/s11596-015-1453-y. Epub 2015 Jun 14.
We genotyped 23 Y-STR loci (DYS576, DYS389I, DYS448, DYS389II, DYS19, DYS391, DYS481, DYS549, DYS533, DYS438, DYS437, DYS570, DYS635, DYS390, DYS439, DYS392, DYS643, DYS393, DYS458, DYS385a/b, DYS456, and GATA-H4) in a sample of 109 unrelated male Chinese people residing in Minnan area and compared the results with those from our previous study on 12 Y-STR. The haplotype diversity and the discrimination capacity of the 23 Y-STR reached 0.9903 and 0.9725, respectively, and the genetic diversity for each locus ranged from 0.321 (DYS391) to 0.955 (DYS385). Besides, we observed a strong correlation between the number of Y-STR markers and the substantial improvement of forensic parameters used to discriminate between individuals. The results indicated that these highly polymorphic Y-STR markers were useful for human identification in forensic cases and paternity tests within the Minnan Han Chinese population.
我们对居住在闽南地区的109名无血缘关系的中国男性样本进行了23个Y染色体短串联重复序列（Y-STR）基因座（DYS576、DYS389I、DYS448、DYS389II、DYS19、DYS391、DYS481、DYS549、DYS533、DYS438、DYS437、DYS570、DYS635、DYS390、DYS439、DYS392、DYS643、DYS393、DYS458、DYS385a/b、DYS456和GATA-H4）的基因分型，并将结果与我们之前对12个Y-STR的研究结果进行比较。23个Y-STR的单倍型多样性和鉴别能力分别达到0.9903和0.9725，每个基因座的遗传多样性范围从0.321（DYS391）到0.955（DYS385）。此外，我们观察到Y-STR标记数量与用于区分个体的法医参数的显著改善之间存在强相关性。结果表明，这些高度多态性的Y-STR标记对于闽南汉族人群法医案件中的身份鉴定和亲子鉴定很有用。
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