Vyskocil A, Emminger S, Malir F, Fiala Z, Tusl M, Ettlerova E, Bernard A
Department of Hygiene, Medical Faculty, Charles University, Hradec Kralové, Czechoslovakia.
Int Arch Occup Environ Health. 1989;61(6):409-11. doi: 10.1007/BF00381033.
Biochemical markers of kidney damage were examined in 37 female workers exposed to an average concentration of 225 mg/m3 of styrene. The concentration of mandelic acid in urine was on the average 759 mg/g creatinine. The mean duration of employment of the exposed subjects was 11 years. The results were compared to those obtained in 35 control female workers matched for age and a number of demographic and lifestyle factors and with no history of exposure to organic solvents. No difference was found in the urinary excretion of albumin, beta 2-microglobulin, retinol-binding protein, total proteins, glucose, lysozyme, lactate dehydrogenase and beta-N-acetyl-D-glucosaminidase. The present study provides thus further evidence that exposure to styrene at the current TLV (215 mg/m3) does not entail any detectable risk for the renal function.
对37名平均接触苯乙烯浓度为225毫克/立方米的女性工人进行了肾损伤生化标志物检测。尿中扁桃酸浓度平均为759毫克/克肌酐。接触组受试者的平均工作年限为11年。将结果与35名年龄、一些人口统计学和生活方式因素相匹配且无有机溶剂接触史的对照女性工人的结果进行了比较。在白蛋白、β2-微球蛋白、视黄醇结合蛋白、总蛋白、葡萄糖、溶菌酶、乳酸脱氢酶和β-N-乙酰-D-氨基葡萄糖苷酶的尿排泄方面未发现差异。因此，本研究进一步证明，在当前阈限值（215毫克/立方米）下接触苯乙烯不会对肾功能造成任何可检测到的风险。
