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一种用于电纺丝收集装置的新设计有助于去除小直径管状支架,并为毛细血管的组织工程铺平了道路。

A new design for electrospinner collecting device facilitates the removal of small diameter tubular scaffolds and paves the way for tissue engineering of capillaries.

作者信息

Sohrabi Abbas, Naderi Mahmood, Gorjipour Fazel, Ghamgosar Abolfazl, Ahmadbeigi Naser

机构信息

SABZ Biomedicals Research Center, Tehran, Iran.

Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Tehran, Iran.

出版信息

Exp Cell Res. 2016 Sep 10;347(1):60-64. doi: 10.1016/j.yexcr.2016.07.012. Epub 2016 Jul 19.

Abstract

Electrospinning is a technique widely used for tissue engineering. Despite hurdles, electrospun vascular tissue scaffolds has shown great promise in in vitro studies. One problem is the removal of tubular scaffolds from a electrospinning collection device with no unwanted crumpling or tearing, especially for small diameter scaffolds. To tackle this problem we designed a collection device for simple removal of the scaffold from the collector while no chemical pretreatment was required. The scaffolds fabricated on this collecting device maintained their tubular structure and showed favorable surface properties, mechanical strength and biocompatibility. The device offers a new opportunity for tissue engineering researchers to fabricate tubular scaffolds from materials which have not been possible to date and help them improve the quality of synthesized scaffolds.

摘要

静电纺丝是一种广泛应用于组织工程的技术。尽管存在障碍,但静电纺丝血管组织支架在体外研究中已显示出巨大的潜力。一个问题是如何从静电纺丝收集装置中取出管状支架,而不会出现不必要的褶皱或撕裂,特别是对于小直径支架。为了解决这个问题,我们设计了一种收集装置,无需化学预处理即可从收集器中简单地取出支架。在该收集装置上制造的支架保持了其管状结构,并显示出良好的表面性能、机械强度和生物相容性。该装置为组织工程研究人员提供了一个新的机会,使他们能够用迄今为止无法使用的材料制造管状支架,并帮助他们提高合成支架的质量。

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