对11例着色性干皮病患者的皮肤肿瘤及2例肿瘤前病变进行细胞遗传学研究。

Cytogenetic study on eleven cutaneous neoplasms and two pre-tumoral lesions from Xeroderma pigmentosum patients.

作者信息

Aledo R, Dutrillaux B, Lombard M, Aurias A

机构信息

C.N.R.S. URA 620, Structure et Mutagénèse Chromosomiques, Institut Curie, Paris, France.

出版信息

Int J Cancer. 1989 Jul 15;44(1):79-83. doi: 10.1002/ijc.2910440115.

DOI:10.1002/ijc.2910440115

PMID:2744901

Abstract

Eleven independent tumors (5 basa-cell carcinomas, 5 squamous-cell carcinomas and 1 malignant melanoma), 2 pretumoral lesions and one common nevus, developing in the skin of 10 unrelated XP patients were cytogenetically analyzed. No specific chromosomal changes were observed. Two features were relevant, however: emergence of several independent clones and over-involvement of telomeric and centromeric regions in the formation of chromosomal rearrangements. Jumping translocations were observed in 2 squamous-cell carcinomas involving telomeric and centromeric regions.

摘要

对10名无亲缘关系的着色性干皮病患者皮肤上出现的11个独立肿瘤（5例基底细胞癌、5例鳞状细胞癌和1例恶性黑色素瘤）、2个肿瘤前病变和1个普通痣进行了细胞遗传学分析。未观察到特定的染色体变化。然而，有两个特征值得关注：出现了几个独立的克隆，以及端粒和着丝粒区域在染色体重排形成过程中的过度参与。在2例涉及端粒和着丝粒区域的鳞状细胞癌中观察到跳跃性易位。