Aledo R, Aurias A, Avril M F, Dutrillaux B
CNRS URA 620, Institut Curie, Section de Biologie, Paris, France
Cancer Genet Cytogenet. 1989 Jul 1;40(1):95-103. doi: 10.1016/0165-4608(89)90150-7.
Cytogenetic studies of a skin squamous cell carcinoma from a xeroderma pigmentosum patient were performed at several passages. They show the existence of recurrent rearrangements: 53% were dicentrics, of which 67% were of the telomere-telomere type. The telomeric region of the long arm of chromosome 12 was the most involved (in 38% of dicentrics), followed by 22p. The origin of this type of jumping rearrangement and its possible role on cell proliferation are discussed.
