Duran Charity G, Burbank Allison J, Mills Katherine H, Duckworth Heather R, Aleman Maria M, Kesic Matthew J, Peden David B, Pan Yinghao, Zhou Haibo, Hernandez Michelle L
UNC Center for Environmental Medicine, Asthma, & Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Physical Therapy, Methodist University, Fayetteville, NC, USA.
Respir Res. 2016 Jul 22;17(1):89. doi: 10.1186/s12931-016-0406-8.
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation.
NCT01625130 . Registered 19 June, 2012.
萝卜硫素（SFN）是十字花科蔬菜中天然存在的异硫氰酸盐，通过诱导转录因子NF-E2相关因子2（NRF2）被认为可能是一种治疗气道炎症的方法。在这项概念验证性临床研究中，我们发现，在健康人体受试者中补充含有萝卜硫素的西兰花芽匀浆，在臭氧暴露模型中并未诱导抗氧化基因的表达，也不能预防中性粒细胞性气道炎症。因此，补充膳食萝卜硫素并不是针对气道炎症进行大规模临床试验的有前景的候选方法。
NCT01625130。于2012年6月19日注册。
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