双酚 A 和邻苯二甲酸酯与越南儿童性早熟的关系。
The relationship between bisphenol A and phthalates with precocious puberty in Vietnamese children.
机构信息
Department of Pediatrics, 249295 University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City, Vietnam.
Nephrology and Endocrinology Department, Children's Hospital 2, Ho Chi Minh City, Vietnam.
出版信息
J Pediatr Endocrinol Metab. 2024 Jun 4;37(7):644-651. doi: 10.1515/jpem-2024-0144. Print 2024 Jul 26.
OBJECTIVES
This study is aimed to explore the correlation between bisphenol A (BPA) and phthalates, including diethylhexylphthalate (DEHP) and dibutylphthalate (DBP), and precocious puberty (PP).
METHODS
A case-control study was conducted in Ho Chi Minh City, Vietnam, from November 2021 to April 2022, involving 250 children, with 124 of them diagnosed with PP and 126 serving as controls. We assessed the levels of urinary BPA, DEHP, and DBP in all participants and examined their association with the risk of PP.
RESULTS
BPA was detected in 11.3 % of PP cases but was not found in any individuals in the control group (p<0.001). Diethylhexylphthalate metabolite (MEHP) was not detected in any of the samples. Positive urinary results for dibutylphthalate metabolite (MBP) were observed in 8.1 % of PP cases and 2.4 % in the control group, with an odds ratio of 3.6 (95 % confidence interval: 0.97-13.4, p=0.03).
CONCLUSIONS
The PP group exhibited a higher prevalence of positive urinary BPA and DBP levels compared to the control group.
目的
本研究旨在探讨双酚 A（BPA）与邻苯二甲酸酯（包括邻苯二甲酸二乙酯（DEHP）和邻苯二甲酸二丁酯（DBP））与性早熟（PP）之间的相关性。
方法
本病例对照研究于 2021 年 11 月至 2022 年 4 月在越南胡志明市进行，共纳入 250 名儿童，其中 124 名被诊断为性早熟，126 名为对照组。我们评估了所有参与者尿液中 BPA、DEHP 和 DBP 的水平，并研究了它们与性早熟风险的关系。
结果
在性早熟组中，有 11.3%的病例检测到 BPA，但对照组中未发现任何 BPA（p<0.001）。未检测到邻苯二甲酸二乙酯代谢物（MEHP）。性早熟组中 8.1%的病例和对照组中 2.4%的病例检测到邻苯二甲酸二丁酯代谢物（MBP）阳性，比值比为 3.6（95%置信区间：0.97-13.4，p=0.03）。
结论
与对照组相比，性早熟组尿液中 BPA 和 DBP 水平的阳性率更高。
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