Newsom S W, Eden C G, Wells F C, Meredith P
Department of Microbiology, Papworth Hospital, Cambridge, UK.
J Antimicrob Chemother. 1989 Jan;23(1):113-5. doi: 10.1093/jac/23.1.113.
For a study of penetration of enoxacin into lung, patients undergoing pneumonectomy were given 400 mg by mouth the night before and again approx 2 h before operation. A blood sample was taken as the lung was excised. Lung and serum enoxacin concentrations were assayed by high pressure liquid chromatography. Results from 15 patients showed that enoxacin was concentrated in the lung. Enoxacin lung concentrations were 3.2-13.1 mg/l, and ratios of lung to serum concentrations were 3-6 (mean, 4.2).
为研究依诺沙星在肺部的渗透情况，对接受肺切除术的患者在术前一晚口服400毫克，术前约2小时再次口服。在切除肺脏时采集血样。采用高压液相色谱法测定肺组织和血清中依诺沙星的浓度。15例患者的结果显示，依诺沙星在肺中浓集。肺组织中依诺沙星浓度为3.2 - 13.1毫克/升，肺组织与血清浓度之比为3 - 6（平均为4.2）。
