Barry A L, Jones R N
Clinical Microbiology Institute, Tualatin, Oregon 97062.
J Antimicrob Chemother. 1989 Apr;23(4):527-35. doi: 10.1093/jac/23.4.527.
Tosufloxacin (A-61827) is the tosylate salt of A-60969 (T-3262). Temafloxacin (A-62254) is the hydrochloride salt of A-63004. Both compounds were tested against 945 aerobic bacterial isolates and their in-vitro activities were compared to those of five other fluoroquinolones. Ciprofloxacin and tosufloxacin were similar in their activity against the Enterobacteriaceae and Pseudomonas species. Temafloxacin and ofloxacin were similar in their activity against the Gram-negative bacilli. Strains that were susceptible to ciprofloxacin were also susceptible to ofloxacin, temafloxacin and tosufloxacin. Against nalidixic acid-resistant enteric bacilli, the potency of all seven fluoroquinolones was compromised. Enoxacin and fleroxacin were the least active drugs against Gram-positive species. Tosufloxacin was particularly active against the Gram-positive species; ciprofloxacin, difloxacin and temafloxacin were less active.
妥舒沙星（A - 61827）是A - 60969（T - 3262）的甲苯磺酸盐。替马沙星（A - 62254）是A - 63004的盐酸盐。对这两种化合物针对945株需氧细菌分离株进行了测试，并将它们的体外活性与其他五种氟喹诺酮类药物的活性进行了比较。环丙沙星和妥舒沙星对肠杆菌科和假单胞菌属的活性相似。替马沙星和氧氟沙星对革兰氏阴性杆菌的活性相似。对环丙沙星敏感的菌株对氧氟沙星、替马沙星和妥舒沙星也敏感。对于耐萘啶酸的肠道杆菌，所有七种氟喹诺酮类药物的效力均受到影响。依诺沙星和氟罗沙星对革兰氏阳性菌的活性最低。妥舒沙星对革兰氏阳性菌特别有效；环丙沙星、双氟沙星和替马沙星的活性较低。
