几种新型氟喹诺酮类和β-内酰胺类抗菌药物对社区分离肺炎链球菌的体外活性比较
Comparative in vitro activities of several new fluoroquinolones and beta-lactam antimicrobial agents against community isolates of Streptococcus pneumoniae.
作者信息
Mazzulli T, Simor A E, Jaeger R, Fuller S, Low D E
机构信息
Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
出版信息
Antimicrob Agents Chemother. 1990 Mar;34(3):467-9. doi: 10.1128/AAC.34.3.467.
Abstract
The in vitro susceptibilities of 551 community isolates of Streptococcus pneumoniae from the Canadian province of Ontario to several new fluoroquinolones and beta-lactam antimicrobial agents were determined by a broth microdilution technique. Eight (1.5%) of these isolates were moderately susceptible (MICs, greater than or equal to 0.12 and less than or equal to 1.0 microgram/ml) to penicillin; none was resistant. Temafloxacin, ciprofloxacin, and ofloxacin (MICs for 90% of strains tested, between 1 and 2 micrograms/ml) were the most active fluoroquinolones tested, and BMY-28100 (MIC for 90% of strains tested, 0.25 microgram/ml) was the most active of the new beta-lactams tested.
摘要
采用肉汤微量稀释技术测定了来自加拿大安大略省的551株社区分离肺炎链球菌对几种新型氟喹诺酮类和β-内酰胺类抗菌药物的体外敏感性。这些分离株中有8株（1.5%）对青霉素中度敏感（MICs，大于或等于0.12且小于或等于1.0微克/毫升）；无耐药株。替马沙星、环丙沙星和氧氟沙星（90%受试菌株的MICs在1至2微克/毫升之间）是所测试的活性最强的氟喹诺酮类药物，而BMY-28100（90%受试菌株的MIC为0.25微克/毫升）是所测试的活性最强的新型β-内酰胺类药物。
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