Bryan J P, Waters C, Sheffield J, Krieg R E, Perine P L, Wagner K
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Antimicrob Agents Chemother. 1990 Feb;34(2):368-70. doi: 10.1128/AAC.34.2.368.
Tosufloxacin (A-60969 HCl), a new quinolone with broad activity against gram-positive and anaerobic organisms, was compared in vitro with other quinolones against bacterial pathogens of diarrhea. Tosufloxacin was the most active agent against Salmonella spp., Shigella spp., Campylobacter spp., Aeromonas hydrophila, and Vibrio spp. Temafloxacin (A-62254) also demonstrated good activity against these organisms.
托氟沙星(盐酸A-60969)是一种对革兰氏阳性菌和厌氧菌具有广泛活性的新型喹诺酮类药物,在体外将其与其他喹诺酮类药物针对腹泻病原菌进行了比较。托氟沙星对沙门氏菌属、志贺氏菌属、弯曲菌属、嗜水气单胞菌和弧菌属是活性最强的药物。替马沙星(A-62254)对这些菌也显示出良好活性。