Abdoon Ahmed S, Al-Ashkar Emad A, Kandil Omaima M, Shaban Ahmed M, Khaled Hussein M, El Sayed Mostafa A, El Shaer Marwa M, Shaalan Asharaf H, Eisa Wael H, Eldin Amina A Gamal, Hussein Hany A, El Ashkar Mohammad R, Ali Moustafa R, Shabaka Ali A
Animal Reproduction Department, Veterinary Research Division, National Research Center (NRC), Egypt.
Spectroscopy Department, Physics Division, NRC, Egypt.
Nanomedicine. 2016 Nov;12(8):2291-2297. doi: 10.1016/j.nano.2016.07.005. Epub 2016 Jul 22.
Plasmonic photothermal therapy (PPTT) was introduced as a promising treatment of cancer. This work was conducted to evaluate the cytotoxic effect of intratumoral (IT) injection of 75μg gold nanorods (GNRs)/kg of body weight followed by direct exposure to 2 w/cm near infra-red laser light for 10min on ablation of mammary tumor in 10 dogs and 6 cats. Complete blood count (CBC), liver and kidney function were checked before the start of treatment and one month after injection of GNRs. Results showed that 62.5% (10/16), 25% (4/16) and 12.5% (2/16) of treated animals showed complete remission, partial remission and no response, respectively. Tumor was relapsed in 4 cases of initially responding animals (25%). Overall survival rate was extended to 315.5±20.5days. GNRs have no toxic effect on blood profile, liver or kidney functions. In conclusion, GNRs can be safely used for treatment of mammary tumors in dogs and cats.
等离子体光热疗法（PPTT）作为一种有前景的癌症治疗方法被引入。本研究旨在评估向10只犬和6只猫的乳腺肿瘤内注射75μg/千克体重的金纳米棒（GNRs），随后直接暴露于2瓦/平方厘米的近红外激光下10分钟对肿瘤消融的细胞毒性作用。在治疗开始前以及注射GNRs后1个月检查全血细胞计数（CBC）、肝功能和肾功能。结果显示，62.5%（10/16）、25%（4/16）和12.5%（2/16）的治疗动物分别出现完全缓解、部分缓解和无反应。4例初始有反应的动物（25%）出现肿瘤复发。总体生存率延长至315.5±20.5天。GNRs对血液指标、肝功能或肾功能无毒性作用。总之，GNRs可安全用于犬猫乳腺肿瘤的治疗。
