Yu H, Wang Y, Wang S, Sun N
Yantai infectious diseases hospital Yantai China
Yantai infectious diseases hospital Yantai China.
Cell Mol Biol (Noisy-le-grand). 2016 Jun 30;62(7):42-5.
Considering the inconsistent association between miR-499 rs3746444 and the risk of hepatocellular carcinoma (HCC), it is critical to carry out a meta-analysis in order to produce a precise result. Therefore, a meta-analysis was performed. All of the potential eligible studies were screened based on the following databases, including PubMed, EMBASE, Medline and China National Knowledge Internet (CNKI) up to December 2015. The associations between miR-499 rs3746444and HCC susceptibility was quantified using odds ratios (ORs) with its 95% confidence intervals (CIs). Nine case-control articles were included in the analysis. A total of 2593 cases and 3259 controls were included. The pooled OR was 1.27 (95% CI: 1.10 - 1.48, P = 0.002) which suggested thatmiR-499 rs3746444 was significantly associated with an increased the risk of HCC. Subgroup analysis was performed by ethnicity, miR-499 rs3746444 was significantly associated with an increased the risk of HCC in Asians (OR = 1.31, 95% CI = 1.10-1.55; P = 0.002). However, no significant result was found in Caucasians (OR = 1.10, 95% CI = 0.84-1.44; P = 0.49). In addition, miR-499 rs3746444 was significantly associated with an increased the risk of HCC in subjects with HBV infection OR = 1.31, 95% CI = 1.09-1.58; P = 0.004). This study suggested that miR-499 rs3746444 might play an important role in the development of HCC.
鉴于miR-499 rs3746444与肝细胞癌（HCC）风险之间的关联并不一致，开展一项荟萃分析以得出精确结果至关重要。因此，进行了一项荟萃分析。所有潜在的符合条件的研究均基于以下数据库进行筛选，包括截至2015年12月的PubMed、EMBASE、Medline和中国知网（CNKI）。使用比值比（OR）及其95%置信区间（CI）对miR-499 rs3746444与HCC易感性之间的关联进行量化。分析纳入了9篇病例对照文章。共纳入2593例病例和3259例对照。合并OR为1.27（95%CI：1.10 - 1.48，P = 0.002），这表明miR-499 rs3746444与HCC风险增加显著相关。按种族进行亚组分析，miR-499 rs3746444与亚洲人HCC风险增加显著相关（OR = 1.31，95%CI = 1.10 - 1.55；P = 0.002）。然而，在高加索人中未发现显著结果（OR = 1.10，95%CI = 0.84 - 1.44；P = 0.49）。此外，miR-499 rs3746444与HBV感染患者的HCC风险增加显著相关（OR = 1.31，95%CI = 1.09 - 1.58；P = 0.004）。本研究表明，miR-499 rs3746444可能在HCC的发生发展中起重要作用。
