miR-499基因中Rs3746444位点的T>C变异增加肝细胞癌易感性：一项对14812名受试者的荟萃分析
Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects.
作者信息
Jiang Jia-Kai, Chen Han-Shen, Tang Wei-Feng, Chen Yu, Lin Jing
机构信息
Department of General Surgery, Changzhou No. 3 People's Hospital, Changzhou 213000, Jiangsu Province, China.
Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China.
出版信息
World J Gastrointest Oncol. 2023 Jan 15;15(1):171-185. doi: 10.4251/wjgo.v15.i1.171.
BACKGROUND
Recently, many investigations have suggested that the rs3746444 T>C locus in the microRNA (miR)-499 gene may contribute to the occurrence of cancer. However, reports on the association between rs3746444 and hepatocellular carcinoma (HCC) are conflicting.
AIM
To further understand and explore the potential correlation between the single-nucleotide polymorphism of rs3746444 and the incidence of HCC.
METHODS
In this meta-analysis, we obtained electronic literature by searching the PubMed, Embase and Chinese BioMedical Disc databases (through May 20, 2022). All eligible case-control, prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95% confidence intervals were included.
RESULTS
Ultimately, a total of 17 independent studies were included. We identified that rs3746444 was associated with the development of HCC (C T: = 0.019 and CC/CT TT: = 0.016). In Asian individuals, rs3746444 was associated with susceptibility to HCC (C T: = 0.013 and CC/CT TT: = 0.016). In addition, this study identified that the miR-499 rs3746444 locus was associated with susceptibility to HCC in the normal/healthy control subgroup (C T: = 0.034 and CC/CT TT: = 0.024).
CONCLUSION
In summary, this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals.
背景
最近，许多研究表明，微小RNA（miR）-499基因中的rs3746444 T>C位点可能与癌症的发生有关。然而，关于rs3746444与肝细胞癌（HCC）之间关联的报道相互矛盾。
目的
进一步了解和探讨rs3746444单核苷酸多态性与HCC发病率之间的潜在相关性。
方法
在这项荟萃分析中，我们通过检索PubMed、Embase和中国生物医学文献数据库（截至2022年5月20日）获取电子文献。纳入所有符合条件的病例对照研究、前瞻性队列研究或巢式病例对照研究，这些研究需有足够数据来计算比值比及其95%置信区间。
结果
最终，共纳入17项独立研究。我们发现rs3746444与HCC的发生有关（C>T：=0.019，CC/CT>TT：=0.016）。在亚洲个体中，rs3746444与HCC易感性有关（C>T：=0.013，CC/CT>TT：=0.016）。此外，本研究发现miR-499 rs3746444位点在正常/健康对照亚组中与HCC易感性有关（C>T：=0.034，CC/CT>TT：=0.024）。
结论
总之，这项荟萃分析强调，miR-499基因中的rs3746444参与了HCC的发生，尤其是在亚洲个体中。
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