Jiang Jia-Kai, Chen Han-Shen, Tang Wei-Feng, Chen Yu, Lin Jing
Department of General Surgery, Changzhou No. 3 People's Hospital, Changzhou 213000, Jiangsu Province, China.
Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China.
World J Gastrointest Oncol. 2023 Jan 15;15(1):171-185. doi: 10.4251/wjgo.v15.i1.171.
BACKGROUND: Recently, many investigations have suggested that the rs3746444 T>C locus in the microRNA (miR)-499 gene may contribute to the occurrence of cancer. However, reports on the association between rs3746444 and hepatocellular carcinoma (HCC) are conflicting. AIM: To further understand and explore the potential correlation between the single-nucleotide polymorphism of rs3746444 and the incidence of HCC. METHODS: In this meta-analysis, we obtained electronic literature by searching the PubMed, Embase and Chinese BioMedical Disc databases (through May 20, 2022). All eligible case-control, prospective cohort or nested case-control studies with sufficient data for calculating the odds ratios with their 95% confidence intervals were included. RESULTS: Ultimately, a total of 17 independent studies were included. We identified that rs3746444 was associated with the development of HCC (C T: = 0.019 and CC/CT TT: = 0.016). In Asian individuals, rs3746444 was associated with susceptibility to HCC (C T: = 0.013 and CC/CT TT: = 0.016). In addition, this study identified that the miR-499 rs3746444 locus was associated with susceptibility to HCC in the normal/healthy control subgroup (C T: = 0.034 and CC/CT TT: = 0.024). CONCLUSION: In summary, this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals.
背景：最近，许多研究表明，微小RNA（miR）-499基因中的rs3746444 T>C位点可能与癌症的发生有关。然而，关于rs3746444与肝细胞癌（HCC）之间关联的报道相互矛盾。 目的：进一步了解和探讨rs3746444单核苷酸多态性与HCC发病率之间的潜在相关性。 方法：在这项荟萃分析中，我们通过检索PubMed、Embase和中国生物医学文献数据库（截至2022年5月20日）获取电子文献。纳入所有符合条件的病例对照研究、前瞻性队列研究或巢式病例对照研究，这些研究需有足够数据来计算比值比及其95%置信区间。 结果：最终，共纳入17项独立研究。我们发现rs3746444与HCC的发生有关（C>T：=0.019，CC/CT>TT：=0.016）。在亚洲个体中，rs3746444与HCC易感性有关（C>T：=0.013，CC/CT>TT：=0.016）。此外，本研究发现miR-499 rs3746444位点在正常/健康对照亚组中与HCC易感性有关（C>T：=0.034，CC/CT>TT：=0.024）。 结论：总之，这项荟萃分析强调，miR-499基因中的rs3746444参与了HCC的发生，尤其是在亚洲个体中。
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