MiR-499 rs3746444多态性与肝细胞癌风险：一项荟萃分析。
MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis.
作者信息
Qiu Dapeng, Han Feng, Zhuang Hao
机构信息
Department of Hepato-Biliary- Pancreatic Surgery, Henan Tumor Hospital (The Cancer Hospital Affiliated to Zhengzhou University), Zhengzhou 450008, Henan, China.
出版信息
J Cancer Res Ther. 2018 Jun;14(Supplement):S490-S493. doi: 10.4103/0973-1482.179090.
AIMS
Several studies suggested that miR-499 rs3746444 polymorphism was associated with the risk of hepatocellular carcinoma (HCC). However, other studies did not confirm the result. To derive a more comprehensive estimation of the association between miR-499 rs3746444 polymorphism and HCC risk, we conducted a meta-analysis.
MATERIALS AND METHODS
PUBMED, COCHRANE, and WEB OF SCIENCE databases were retrieved for the association studies focused on the relationship between miR-499 rs3746444 polymorphism and the risk of HCC. The strength of the associations between miR-499 rs3746444 polymorphism and the risk of HCC was measured by odds ratios (ORs) with 95% confidence intervals (CIs).
RESULTS
A statistically significant association between miR-499 rs3746444 polymorphism and the risk of HCC was fond (OR = 1.26; 95% CI, 1.04-1.52; P = 0.02). In the subgroup analysis of race, Asian population with miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.29; 95% CI, 1.03-1.62; P = 0.03). In the subgroup analysis of hepatitis virus status, patients with HBV and miR-499 rs3746444 polymorphism showed increased HCC risk (OR = 1.38; 95% CI, 1.17-1.64; P = 0.0002). In the subgroup analysis of source of control, both hospital- and population-based studies found significant results (OR = 1.46; 95% CI, 1.12-1.90; P = 0.005; OR = 1.19; 95% CI, 1.01-1.40; P = 0.04).
CONCLUSIONS
This meta-analysis suggested that mir-499 rs3746444 polymorphism was associated with an increased HCC risk.
目的
多项研究表明，miR-499 rs3746444多态性与肝细胞癌（HCC）风险相关。然而，其他研究并未证实这一结果。为了更全面地评估miR-499 rs3746444多态性与HCC风险之间的关联，我们进行了一项荟萃分析。
材料与方法
检索PUBMED、COCHRANE和科学网数据库，查找聚焦于miR-499 rs3746444多态性与HCC风险关系的关联研究。miR-499 rs3746444多态性与HCC风险之间关联的强度用比值比（OR）及95%置信区间（CI）衡量。
结果
发现miR-499 rs3746444多态性与HCC风险之间存在统计学显著关联（OR = 1.26；95% CI，1.04 - 1.52；P = 0.02）。在种族亚组分析中，具有miR-499 rs3746444多态性的亚洲人群HCC风险增加（OR = 1.29；95% CI，1.03 - 1.62；P = 0.03）。在肝炎病毒状态亚组分析中，患有乙肝且具有miR-499 rs3746444多态性的患者HCC风险增加（OR = 1.38；95% CI，1.17 - 1.64；P = 0.0002）。在对照来源亚组分析中，基于医院和基于人群的研究均得到显著结果（OR = 1.46；95% CI，1.12 - 1.90；P = 0.005；OR = 1.19；95% CI，1.01 - 1.40；P = 0.04）。
结论
这项荟萃分析表明，mir-499 rs3746444多态性与HCC风险增加相关。
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