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厨房用具中聚酰胺环状低聚物的分离与定量及其向各种食品模拟物中的迁移

Isolation and Quantification of Polyamide Cyclic Oligomers in Kitchen Utensils and Their Migration into Various Food Simulants.

作者信息

Abe Yutaka, Mutsuga Motoh, Ohno Hiroyuki, Kawamura Yoko, Akiyama Hiroshi

机构信息

National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo, Japan.

Nagoya City Public Health Research Institute, Hagiyama-cho, Mizuho-ku, Nagoya, Japan.

出版信息

PLoS One. 2016 Jul 25;11(7):e0159547. doi: 10.1371/journal.pone.0159547. eCollection 2016.

DOI:10.1371/journal.pone.0159547
PMID:27453976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4959713/
Abstract

Small amounts of cyclic monomers and oligomers are present in polyamide (PA)-based kitchen utensils. In this study, we isolated eight PA-based cyclic monomers and oligomers from kitchen utensils made from PA6 (a polymer of ε-caprolactam) and PA66 (a polymer of 1,6-diaminohexane and adipic acid). Their structures were identified using high-resolution mass spectrometry and 1H- and 13C-nuclear magnetic resonance spectroscopy, and their residual levels in PA-based kitchen utensils and degree of migration into food simulants were quantified by high-performance liquid chromatography/mass spectrometry using purchased PA6 monomer and isolated PA66 monomers, and isolated PA6 and PA66 oligomers as calibration standards. Their total residual levels among 23 PA-based kitchen utensils made from PA6, PA66, and copolymers of PA6 and PA66 (PA6/66) ranged from 7.8 to 20 mg/g. Using water, 20% ethanol, and olive oil as food simulants, the total migration levels of the PA monomers and oligomers ranged from 0.66 to 100 μg/cm2 under most examined conditions. However, the total migration levels of the PA66 monomer and oligomers from PA66 and PA6/66 kitchen utensils into 20% ethanol at 95°C were very high (1,700 and 2,200 μg/cm2, respectively) due to swelling by high-temperature ethanol.

摘要

基于聚酰胺（PA）的厨房用具中存在少量环状单体和低聚物。在本研究中，我们从由PA6（ε-己内酰胺的聚合物）和PA66（1,6-二氨基己烷与己二酸的聚合物）制成的厨房用具中分离出8种基于PA的环状单体和低聚物。使用高分辨率质谱以及1H-和13C-核磁共振光谱对它们的结构进行了鉴定，并以购买的PA6单体、分离出的PA66单体以及分离出的PA6和PA66低聚物作为校准标准品，通过高效液相色谱/质谱法定量了它们在基于PA的厨房用具中的残留水平以及向食品模拟物中的迁移程度。在23种由PA6、PA66以及PA6和PA66的共聚物（PA6/66）制成的基于PA的厨房用具中，它们的总残留水平在7.8至20 mg/g之间。使用水、20%乙醇和橄榄油作为食品模拟物，在大多数检测条件下，PA单体和低聚物的总迁移水平在0.66至100 μg/cm2之间。然而，由于高温乙醇导致溶胀，PA66单体和低聚物从PA66和PA6/66厨房用具向95°C的20%乙醇中的总迁移水平非常高（分别为1700和2200 μg/cm2）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/8477e656b8ed/pone.0159547.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/056044a8c8d6/pone.0159547.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/09c70a491ac8/pone.0159547.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/b5876737a8d7/pone.0159547.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/1fcad33f8283/pone.0159547.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/8477e656b8ed/pone.0159547.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/056044a8c8d6/pone.0159547.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/09c70a491ac8/pone.0159547.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/b5876737a8d7/pone.0159547.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/1fcad33f8283/pone.0159547.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2c/4959713/8477e656b8ed/pone.0159547.g005.jpg

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