Jiyang College of Zhejiang Agriculture and Forestry University, Zhuji, 311800, P. R. China.
Chem Biodivers. 2016 Dec;13(12):1611-1616. doi: 10.1002/cbdv.201600018. Epub 2016 Nov 16.
Five novel iridoid glycosides, avellanedaesides A-E (1 - 5) were isolated from the H O extract of Tabebuia avellanedae. Their structures were determined on the basis of NMR and MS analysis. Isolated compounds suppressed inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide (LPS). In addition, the study revealed iridoid glycosides inhibited the activity of cytochrome CYP3A4 enzyme.
从 Tabebuia avellanedae 的 H2O 提取物中分离得到了 5 种新型的环烯醚萜糖苷，分别为 avellanedaesides A-E（1-5）。基于 NMR 和 MS 分析确定了它们的结构。分离得到的化合物可抑制脂多糖（LPS）刺激培养的人骨髓瘤 THP-1 细胞中炎性细胞因子、肿瘤坏死因子-α和白细胞介素-1β的产生。此外，该研究表明环烯醚萜糖苷可抑制细胞色素 CYP3A4 酶的活性。
