Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Molecules. 2013 Jun 24;18(7):7336-45. doi: 10.3390/molecules18077336.
Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC₅₀ of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.
从 Tabebuia avellanedae 的水提取物中分离得到三个新的苯丙素糖苷 2、5、6，以及三个已知的苯丙素糖苷 1、3、4。所有化合物均基于光谱分析和化学方法进行鉴定，对于已知化合物，则通过与已发表的数据进行比较进行鉴定。所有分离得到的化合物在 DPPH 测定中均表现出很强的抗氧化活性，其中化合物 5 的抗氧化活性最高，IC₅₀为 0.12 µM。所有化合物对细胞色素 CYP3A4 酶均表现出中等抑制作用。
