• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TGF-beta stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides.

作者信息

Soma Y, Grotendorst G R

机构信息

Department of Ophthalmology, University of South Florida College of Medicine, Tampa 33612.

出版信息

J Cell Physiol. 1989 Aug;140(2):246-53. doi: 10.1002/jcp.1041400209.

DOI:10.1002/jcp.1041400209
PMID:2745561
Abstract

Transforming growth factor-beta (TGF-beta) stimulates DNA synthesis in human foreskin fibroblasts after a prolonged lag period as compared with other growth factors. The mechanism of induction of DNA synthesis appears to be dependent on the synthesis and secretion of PDGF-related proteins as antibodies which are specific for PDGF can block the TGF-beta-induced DNA synthesis. Other growth factors such as PDGF, EGF, or FGF do not induce the synthesis of these PDGF-related proteins. Additionally, TGF-beta treatment of human foreskin fibroblasts induces the expression of the PDGF A-chain gene but not the B-chain gene. This phenomenon appears to function in vivo, as subcutaneous injection of TGF-beta in rat skin induces the expression of the PDGF A-chain gene. These data suggest that TGF-beta may stimulate the growth of fibroblastic cells via an autocrine production of PDGF-related proteins.

摘要

相似文献

1
TGF-beta stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides.
J Cell Physiol. 1989 Aug;140(2):246-53. doi: 10.1002/jcp.1041400209.
2
The growth-inhibitory block of TGF-beta is located close to the G1/S border in the cell cycle.转化生长因子β（TGF-β）的生长抑制阻滞位于细胞周期中靠近G1/S边界的位置。
Exp Cell Res. 1995 Apr;217(2):477-83. doi: 10.1006/excr.1995.1112.
3
Altered growth factor sensitivity in EL2 rat fibroblasts: influence of this biological characteristic on cell growth.EL2大鼠成纤维细胞中生长因子敏感性的改变：这种生物学特性对细胞生长的影响。
Eur J Cell Biol. 1989 Jun;49(1):196-201.
4
TGF-beta regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2.转化生长因子-β通过蛋白激酶A的激活和成纤维细胞生长因子-2的自分泌作用，对胎儿和成人人类皮肤成纤维细胞的增殖进行差异性调节。
Cell Signal. 2006 Sep;18(9):1417-29. doi: 10.1016/j.cellsig.2005.11.002. Epub 2005 Dec 19.
5
Mitogenic effect of transforming growth factor beta 1 on human fibroblasts involves the induction of platelet-derived growth factor alpha receptors.转化生长因子β1对人成纤维细胞的促有丝分裂作用涉及血小板衍生生长因子α受体的诱导。
J Cell Physiol. 1990 Oct;145(1):181-6. doi: 10.1002/jcp.1041450124.
6
CDGF (chicken embryo fibroblast-derived growth factor) is mitogenically related to TGF-beta and modulates PDGF, bFGF, and IGF-I action on sparse NIH/3T3 cells.鸡胚成纤维细胞衍生生长因子（CDGF）与转化生长因子-β（TGF-β）在促有丝分裂方面相关，并调节血小板衍生生长因子（PDGF）、碱性成纤维细胞生长因子（bFGF）和胰岛素样生长因子-I（IGF-I）对稀疏的NIH/3T3细胞的作用。
Exp Cell Res. 1993 Feb;204(2):329-35. doi: 10.1006/excr.1993.1040.
7
FGF-2, IL-1beta and TGF-beta regulate fibroblast expression of S100A8.成纤维细胞生长因子-2、白细胞介素-1β和转化生长因子-β调节S100A8在成纤维细胞中的表达。
FEBS J. 2005 Jun;272(11):2811-27. doi: 10.1111/j.1742-4658.2005.04703.x.
8
Induction and modulation of anchorage-independent growth by platelet-derived growth factor, fibroblast growth factor, and transforming growth factor-beta.血小板衍生生长因子、成纤维细胞生长因子和转化生长因子-β对非锚定依赖性生长的诱导与调节
Cancer Res. 1986 Jun;46(6):2816-20.
9
High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells.高葡萄糖浓度通过激活人系膜细胞中的血小板衍生生长因子环来诱导转化生长因子-β的过表达。
Am J Pathol. 1996 Dec;149(6):2095-106.
10
Specific inhibition of human skin fibroblast chemotaxis to platelet-derived growth factor A-chain homodimer by transforming growth factor-beta1.转化生长因子-β1对人皮肤成纤维细胞向血小板衍生生长因子A链同二聚体趋化性的特异性抑制作用
Arch Dermatol Res. 2002 Feb;293(12):609-13. doi: 10.1007/s00403-001-0279-6. Epub 2002 Jan 23.

引用本文的文献

1
Serum IgA levels and survival in patients with idiopathic pulmonary fibrosis: association with serum cytokine levels and peripheral monocyte counts.特发性肺纤维化患者的血清IgA水平与生存率：与血清细胞因子水平及外周血单核细胞计数的关联
J Thorac Dis. 2025 Apr 30;17(4):2038-2049. doi: 10.21037/jtd-2024-2142. Epub 2025 Apr 28.
2
Serum levels of the -terminal fragment of connective tissue growth factor is a novel biomarker for chronic pancreatitis.血清中结缔组织生长因子的羧基末端片段水平是慢性胰腺炎的一种新型生物标志物。
Pract Lab Med. 2024 May 18;40:e00402. doi: 10.1016/j.plabm.2024.e00402. eCollection 2024 May.
3
TGF-β-target genes are differentially regulated in corneal epithelial cells and fibroblasts.
转化生长因子-β（TGF-β）靶基因在角膜上皮细胞和成纤维细胞中受到不同的调控。
New Front Ophthalmol. 2017;3(1). doi: 10.15761/NFO.1000151. Epub 2017 Jan 30.
4
Fibroblasts in fibrosis: novel roles and mediators.纤维化中的成纤维细胞：新作用与介质
Front Pharmacol. 2014 May 27;5:123. doi: 10.3389/fphar.2014.00123. eCollection 2014.
5
The mechanism of protracted wound healing on oral mucosa in diabetes. Review.糖尿病患者口腔黏膜迁延性愈合的机制。综述。
Bosn J Basic Med Sci. 2010 Aug;10(3):186-91. doi: 10.17305/bjbms.2010.2683.
6
Corneal stroma PDGF blockade and myofibroblast development.角膜基质血小板衍生生长因子阻断与肌成纤维细胞发育
Exp Eye Res. 2009 May;88(5):960-5. doi: 10.1016/j.exer.2008.12.006. Epub 2008 Dec 24.
7
TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases.转化生长因子-β1通过丝裂原活化蛋白激酶的磷酸化作用增加气道平滑肌细胞的增殖。
Respir Res. 2006 Jan 3;7(1):2. doi: 10.1186/1465-9921-7-2.
8
Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop.近端肾小管上皮细胞长期暴露于葡萄糖会通过自分泌血小板衍生生长因子（PDGF）环诱导转化生长因子-β1的合成。
Am J Pathol. 2003 Dec;163(6):2565-74. doi: 10.1016/s0002-9440(10)63611-5.
9
Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring.成纤维细胞介导转化生长因子-β(1)刺激的基质收缩：结缔组织生长因子在收缩性瘢痕形成中的作用。
Am J Pathol. 2003 Nov;163(5):2043-52. doi: 10.1016/s0002-9440(10)63562-6.
10
Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice.非复制性腺病毒作为载体滴定法，用于转导活性转化生长因子-β1基因表达，从而在C57BL/6小鼠肺部引发炎症和纤维化。
Int J Exp Pathol. 2002 Aug;83(4):183-201. doi: 10.1046/j.1365-2613.2002.00229.x.