Kawamura Tatsuyoshi
Nihon Rinsho. 2016 Jul;74(7):1144-9.
Abstract Acrodermatitis enteropathica(AE) is caused by inherited or acquired zinc deficiency. Cutaneous clinical manifestations observed in AE include characteristic dermatitis on acral, periorificial and anogenital areas through an unknown mechanism. Recently, we found that mice fed a zinc-deficient diet develop a severe irritant contact dermatitis that has the histological features of the skin inflammation seen in AE patients. This finding highlights the possibility that the acral, periorificial and anogenital dermatitis in AE might be caused by contact with different irritants in daily life, such as chemicals, foods, urine or feces, respectively. This review focuses on the recent advances regarding the functional role of zinc in skin and describes how zinc deficiency causes various cutaneous manifestations.
摘要 肠病性肢端皮炎（AE）由遗传性或获得性锌缺乏引起。AE的皮肤临床表现包括肢端、口周和肛周生殖器区域的特征性皮炎，其发病机制不明。最近，我们发现喂食缺锌饮食的小鼠会发生严重的刺激性接触性皮炎，具有AE患者皮肤炎症的组织学特征。这一发现凸显了AE患者肢端、口周和肛周生殖器皮炎可能分别由日常生活中接触不同刺激物（如化学物质、食物、尿液或粪便）引起的可能性。本综述重点关注锌在皮肤中的功能作用的最新进展，并描述锌缺乏如何导致各种皮肤表现。
