内源性哇巴因：最新进展与争议
Endogenous Ouabain: Recent Advances and Controversies.
作者信息
Hamlyn John M, Blaustein Mordecai P
机构信息
From the Departments of Physiology (J.M.H., M.P.B.) and Medicine (M.P.B.), University of Maryland School of Medicine, Baltimore.
出版信息
Hypertension. 2016 Sep;68(3):526-32. doi: 10.1161/HYPERTENSIONAHA.116.06599. Epub 2016 Jul 25.
Abstract
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid (CTS). This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of α2 Na pumps and their CTS binding site are also discussed.
摘要
在这篇简短的文章中，我们总结了关于内源性哇巴因（EO）——一种强心甾体（CTS）的近期报道。这包括对哺乳动物EO的分析、EO异构体的发现、EO对细胞内信号传导的调节，以及EO在高血压、妊娠、心脏和肾脏疾病中的作用。还讨论了阐明α2钠泵及其CTS结合位点关键作用的新型哇巴因抗性小鼠。
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