Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Łukasiewicza 1, 85-821 Bydgoszcz, Poland.
Department of Obstetrics and Gynecology, St. Adalbert's Hospital in Gdańsk, Copernicus Healthcare Entity, Jana Pawła II 50, 80-462 Gdańsk, Poland.
Int J Mol Sci. 2023 Aug 13;24(16):12743. doi: 10.3390/ijms241612743.
(PE), the most severe presentation of hypertensive disorders of pregnancy, is the major cause of morbidity and mortality linked to pregnancy, affecting both mother and fetus. Despite advances in prophylaxis and managing PE, delivery of the fetus remains the only causative treatment available. Focus on complex pathophysiology brought the potential for new treatment options, and more conservative options allowing reduction of feto-maternal complications and sequelae are being investigated. Endogenous digitalis-like factors, which have been linked to the pathogenesis of preeclampsia since the mid-1980s, have been shown to play a role in the pathogenesis of various cardiovascular diseases, including congestive heart failure and chronic renal disease. Elevated levels of EDLF have been described in pregnancy complicated by hypertensive disorders and are currently being investigated as a therapeutic target in the context of a possible breakthrough in managing preeclampsia. This review summarizes mechanisms implicating EDLFs in the pathogenesis of preeclampsia and evidence for their potential role in treating this doubly life-threatening disease.
子痫前期 (PE) 是妊娠高血压疾病中最严重的表现，是与妊娠相关的发病率和死亡率的主要原因，对母婴都有影响。尽管在预防和治疗 PE 方面取得了进展，但分娩仍然是唯一可行的治疗方法。对复杂病理生理学的关注带来了新的治疗选择的潜力，并且正在研究更保守的选择，以减少胎儿-母体并发症和后遗症。自 20 世纪 80 年代中期以来，内源性洋地黄样因子与子痫前期的发病机制有关，已被证明在各种心血管疾病（包括充血性心力衰竭和慢性肾病）的发病机制中发挥作用。在伴有高血压疾病的妊娠中已描述了 EDLF 水平升高，并且目前正在作为一种治疗靶点进行研究，以期在治疗子痫前期方面取得突破性进展。本综述总结了 EDLF 参与子痫前期发病机制的机制，并为其在治疗这种双重危及生命的疾病中的潜在作用提供了证据。
