Das Gupta Esha, Sakthiswary Rajalingham, Lee Shing L, Wong Shew F, Hussein Heselynn, Gun Suk C
Department of Medicine, International Medical University, Seremban, Malaysia.
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Int J Rheum Dis. 2018 Mar;21(3):705-709. doi: 10.1111/1756-185X.12918. Epub 2016 Jul 26.
The main objective of this study is to elucidate the clinical significance of the SLC2A9/GLUT9 rs11722228 polymorphism among male gout patients.
We consecutively recruited all newly diagnosed male gout patients who were treatment-naive from the rheumatology outpatient clinics of two Malaysian hospitals. Age-matched healthy male adults were employed as controls. All subjects were tested for the SLC2A9/GLUT9 rs11722228 genotypes, serum uric acid (SUA), urine uric acid and creatinine levels. All gout subjects were examined for the presence of tophi and sonographically screened for renal calculi.
A total of 73 male gout patients and 73 age-matched healthy male adults were recruited in this study. The genotypic frequencies of SLC2A9/GLUT9 rs1172228 did not differ significantly between the gout cases and the healthy controls. The gout subjects with the CC genotype had significantly higher SUA levels (P = 0.002), family history of gout (P < 0.050) and the occurrence of renal calculi (P = 0.026). The SUA-adjusted odds ratios (OR) of the occurrence of renal calculi in the CC genotype (OR = 1 [reference]) was significantly higher than the CT genotype (OR = 0.338, 95%CI: 0.141-0.813) and the TT genotype (OR = 0.271, 95%CI: 0.086-0.854).
The genotypic distribution of SLC2A9/GLUT9 rs1172228 in male gout patients did not differ significantly from that of healthy male controls. However, the CC genotype in gout had significant associations with higher levels of SUA, renal calculi and a positive family history of gout.
本研究的主要目的是阐明SLC2A9/GLUT9 rs11722228基因多态性在男性痛风患者中的临床意义。
我们连续招募了来自马来西亚两家医院风湿科门诊的所有新诊断的未经治疗的男性痛风患者。年龄匹配的健康男性成年人作为对照。对所有受试者进行SLC2A9/GLUT9 rs11722228基因型、血清尿酸(SUA)、尿尿酸和肌酐水平检测。对所有痛风患者检查是否存在痛风石,并进行肾脏超声结石筛查。
本研究共招募了73例男性痛风患者和73例年龄匹配的健康男性成年人。痛风患者和健康对照者之间SLC2A9/GLUT9 rs1172228的基因型频率无显著差异。CC基因型的痛风患者SUA水平显著更高(P = 0.002)、痛风家族史(P < 0.050)和肾结石发生率(P = 0.026)显著更高。CC基因型(OR = 1[参考值])肾结石发生的SUA校正比值比(OR)显著高于CT基因型(OR = 0.338,95%CI:0.141 - 0.813)和TT基因型(OR = 0.271,95%CI:0.086 - 0.854)。
男性痛风患者中SLC2A9/GLUT9 rs1172228的基因型分布与健康男性对照者无显著差异。然而,痛风中的CC基因型与较高的SUA水平、肾结石和痛风家族史阳性显著相关。