Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, 730030, China.
Hereditas. 2022 Aug 4;159(1):30. doi: 10.1186/s41065-022-00243-y.
Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most important risk factor for gout. In recent years, with the improvement of living standards and the change of dietary habits, the incidence of gout in the world has increased dramatically, and gradually tends to be younger. An increasing number of studies have shown that gene mutations may play an important role in the development of HUA and gout. Therefore, we reviewed the existing literature and summarized the susceptibility genes and research status of HUA and gout, in order to provide reference for the early diagnosis, individualized treatment and the development of new targeted drugs of HUA and gout.
痛风是一种慢性代谢性疾病，严重影响人类健康，也是全球面临的重大挑战之一，给患者和社会带来了沉重的负担。高尿酸血症（HUA）是痛风最重要的危险因素。近年来，随着生活水平的提高和饮食习惯的改变，全球痛风的发病率显著增高，并逐渐趋于年轻化。越来越多的研究表明，基因突变可能在 HUA 和痛风的发生发展中起重要作用。因此，我们复习了目前的文献，总结了 HUA 和痛风的易感基因及其研究现状，以期为 HUA 和痛风的早期诊断、个体化治疗及新型靶向药物的研发提供参考。
