Elshafey Mohamed R, Ahmed Rehab A, Mourad Mohamed I, Gaballah Essam T
Oral Pathology Department, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt.
Pathology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Cancer Biol Med. 2016 Jun;13(2):286-95. doi: 10.20892/j.issn.2095-3941.2016.0037.
Mucoepidermoid carcinoma (MEC) is the most common primary malignancy of the salivary glands. Insulin-like growth factor-II mRNA-binding protein-3 (IMP3) is an important prognostic factor in some cancers and a tool that differentiates between benign and malignant pancreatic lesions. This study aimed to identify a relationship between the expression of IMP3 and the outcome of salivary gland MEC, as well as to differentiate MEC from pleomorphic adenoma (PA).
Tissue specimens from 70 cases of salivary gland MEC, 40 cases of PA, and 10 cases with normal salivary gland were examined immunohistochemically for IMP3. The association among the expression of IMP3, clinicopathological characteristics and patient's survival was assessed.
IMP3 was present in 51.4% of MEC but absent in PA and normal salivary gland tissues. IMP3 expression was associated with age > 60 years, submandibular gland tumors, tumor size > 4 cm, high-grade tumors, lymph node metastasis, involvement of surgical margins, perineural invasion, distant metastasis, advanced TNM stage, tumor relapse, and death ( P<0.05). Increased expression of IMP3, tumors of the submandibular gland, and lymph node metastasis were independent prognostic factors of -free survival (DFS). In addition, IMP3 was a strong predictor of overall survival (OS) together with distant metastasis and intermediate and high-grade tumors.
IMP3 expression is highly important in evaluating the outcome of MEC. IMP3 can be used to differentiate MEC from PA of salivary glands.
黏液表皮样癌（MEC）是唾液腺最常见的原发性恶性肿瘤。胰岛素样生长因子-II mRNA结合蛋白-3（IMP3）是某些癌症的重要预后因素，也是鉴别胰腺良恶性病变的一种工具。本研究旨在确定IMP3表达与唾液腺MEC预后之间的关系，并将MEC与多形性腺瘤（PA）区分开来。
采用免疫组织化学方法检测70例唾液腺MEC、40例PA和10例正常唾液腺组织标本中的IMP3。评估IMP3表达、临床病理特征与患者生存之间的相关性。
IMP3在51.4%的MEC中存在，但在PA和正常唾液腺组织中不存在。IMP3表达与年龄>60岁、下颌下腺肿瘤、肿瘤大小>4 cm、高级别肿瘤、淋巴结转移、手术切缘受累、神经周围浸润、远处转移、TNM分期晚期、肿瘤复发和死亡相关（P<0.05）。IMP3表达增加、下颌下腺肿瘤和淋巴结转移是无病生存期（DFS）的独立预后因素。此外，IMP3与远处转移以及中高级别肿瘤一起是总生存期（OS）的有力预测指标。
IMP3表达在评估MEC预后方面非常重要。IMP3可用于区分唾液腺MEC与PA。
