McMaster Integrative Neuroscience Discovery and Study McMaster University Hamilton Ontario Canada; Mood Disorders Program St. Joseph's Healthcare Hamilton Ontario Canada.
Mood Disorders Program St. Joseph's Healthcare Hamilton Ontario Canada.
Brain Behav. 2016 May 8;6(7):e00474. doi: 10.1002/brb3.474. eCollection 2016 Jul.
Major depressive disorder (MDD) and trauma-related disorders are associated with deficits in remembering the past and imagining the future (i.e., episodic simulation). We examined parental bonding and neuropsychological performance in relation to episodic simulation in trauma-exposed patients with recurrent MDD.
Trauma-exposed patients with MDD (n = 21) and matched controls (n = 20) completed a future-oriented Autobiographical Interview, the Parental Bonding Instrument, and a standardized neuropsychological battery.
Patients with major depressive disorder generated fewer episodic details for future neutral events compared to controls. Although higher reported levels of maternal care were associated with increased specificity of negative future events among the patient group, higher maternal overprotection was related to decreased specificity of negative and positive future events. Higher levels of performance on measures of intelligence, verbal memory, executive functioning, and sustained attention were associated with increased specificity of future events.
Maternal relations during childhood and neuropsychological performance are related to the specificity of episodic simulation in adult patients with MDD. Childhood experience continues to influence memory performance into adulthood.
重度抑郁症（MDD）和与创伤相关的障碍与回忆过去和想象未来（即情景模拟）的能力缺陷有关。我们研究了与创伤后反复发作 MDD 患者的情景模拟有关的父母养育方式和神经心理学表现。
创伤后 MDD 患者（n=21）和匹配的对照组（n=20）完成了面向未来的自传式访谈、父母养育方式问卷和标准化神经心理学测试。
与对照组相比，MDD 患者对未来中性事件的情景细节生成较少。尽管报告的母亲关爱程度较高与患者组中对未来消极事件的特异性增加有关，但母亲过度保护与未来消极和积极事件特异性降低有关。智力、言语记忆、执行功能和持续注意力等测量指标的表现水平较高与未来事件的特异性增加有关。
儿童时期的母婴关系和神经心理学表现与 MDD 成年患者情景模拟的特异性有关。儿童时期的经历会持续影响成年后的记忆表现。
