Gunz F W, Gunz J P, Vincent P C, Bergin M, Johnson F L, Bashir H, Kirk R L
J Natl Cancer Inst. 1978 Jun;60(6):1243-50. doi: 10.1093/jnci/60.6.1243.
Thirteen cases of leukemia, 12 of them acute, occurred in 3 generations of a family comprising 293 members. Individual cases could not be linked to the possession of any of a range of genetic markers. Cytogenetic studies showed no constitutional chromosome abnormalities. Preliminary results of virologic studies suggested the presence of oncornaviruses in at least 1 leukemic individual in this family. This aggregation of leukemia cases likely resulted from a genetic, probably polygenic, predisposition, in association with the activity of leukemogenic factors whose nature remains to be clearly defined.
在一个由293名成员组成的三代家族中发生了13例白血病，其中12例为急性白血病。个别病例与一系列遗传标志物中的任何一种均无关联。细胞遗传学研究显示没有先天性染色体异常。病毒学研究的初步结果表明该家族中至少有1名白血病患者体内存在致癌RNA病毒。这种白血病病例的聚集可能是由一种遗传性的、可能是多基因的易感性，与致癌因子的活性共同作用导致的，而致癌因子的性质仍有待明确界定。
