[人类白血病和淋巴瘤中的定型染色体异常]
[Stereotyped chromosome abnormalities in human leukemia and lymphoma].
作者信息
Berger R
出版信息
Presse Med. 1983 Dec 17;12(46):2937-41.
PMID:6228876
Abstract
That chromosomal abnormalities in leukaemias and lymphomas are not non-randomly distributed has been demonstrated by banding techniques. Abnormalities characteristic of a given type of proliferation are described. The chromosomal breakpoints corresponding to these changes are located close to the sequences encoding for cellular oncogens (c-onc), which justifies the growing interest in the cytogenetic study of malignant cells.
摘要
染色体显带技术已证实，白血病和淋巴瘤中的染色体异常并非随机分布。文中描述了特定类型增殖所特有的异常情况。与这些变化相对应的染色体断点位于靠近细胞癌基因（c-onc）编码序列的位置，这使得人们对恶性细胞的细胞遗传学研究兴趣日益浓厚。
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